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| hyper-IgM | ? | +/= | - | - | = |
| hyper-IgE | ? | = | = | = | + |
| CVID | ? | - | - | - | - |
| IgAD | ? | ? | ? | - | ? |
| IgG deficiency | = | = | - | = | = |
| liver
cirrhosis |
? | ? | ? | + | ? |
hereditary periodic fever syndromes / hereditary autoinflammatory disorders are a group of systemic disorders characterized by recurrent attacks of systemic inflammation (autoinflammation) without infectious or autoimmune cause, resulting from a defect of the innate immune responseref (Kastner DL, Aksentijevich I. Intermittent and periodic arthritis syndromes. In: Koopman WJ, Moreland LW, eds. Arthritis and Allied Conditions (15th ed). Philadelphia: Lippincott Williams and Wilkins; 2005:1411–1461), initially described as affecting primarily the serosal and synovial surfaces and the skin, but now recognized to include a somewhat broader distribution of affected tissues. The hereditary periodic fevers differ from autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis in that they lack high-titer autoantibodies or antigen-specific T-cells; they are termed autoinflammatory diseases to highlight this distinction