Here are some other interesting bioscience- and non-bioscience-related
contributes, selected according to my opinions : I hope you find them useful.
Please give me your suggestions
!
life : the aggregate of vital phenomena; a certain peculiar stimulated
condition of organized matter; that obscure principle whereby organized
beings are peculiarly endowed with certain powers and functions not associated
with inorganic matter. Generally, living things share, in varying degrees,
the following characteristics: organization, irritability, movement, growth,
reproduction, and adaptation.
terrestrial life
intrauterine or uterine life : the period of life spent in the uterus;
i.e., embryonic and fetal life.
extrauterine life : the period of life spent outside the uterus
extraterrestrial life
vegetative life : that which is manifested in automatic acts requisite
for the maintenance of the individual and the propagation of the species.
animal life : vegetative life conjoined with the employment of the
senses and with spontaneous movements.
comparative medicine : the study of phenomena basic to the diseases
of all species.
physiatry / physiatrics / physical medicine : the branch of medicine
that deals with the prevention, diagnosis, and treatment of disease or
injury, and the rehabilitation from resultant impairments and disabilities,
using physical agents such as light, heat, cold, water, electricity, therapeutic
exercise, and mechanical apparatus, and sometimes pharmaceutical agents
psychosomatic medicine : a system of medicine which aims at discovering
the nature of the relationship of the emotions and bodily function, affirming
the principle that the mind and body are one, as well as emphasizing psychosocial
aspects of medical care
behavioral medicine : a segment of psychosomatic medicine focussed
on psychological means of influencing physical symptoms, such as biofeedback
or relaxation
socialized or state medicine : a system of medical care regulated
and controlled by the government, in which the government assumes responsibility
for providing for the health needs and hospital care of the entire population,
at no direct cost or at a nominal fee to the individual, by means of subsidies
obtained by taxation
sanitarian : a person who is expert in matters of sanitation and
public health.
doctor : 1. a practitioner of the healing arts, one who has received
a degree from a college of medicine, osteopathy, chiropractic, optometry,
podiatry, pharmacy, dentistry, or veterinary medicine, licensed to practice
by a state. 2. a holder of a diploma of the highest degree from a
university, qualified as a specialist in a particular field of learning
physician : an authorized practitioner of
medicine, as one graduated from a college of medicine or osteopathy and
licensed by the appropriate board.
physician assistant (P.A) : one who has been trained in an accredited
program and certified by an appropriate board to perform certain of a physician's
duties, including history taking, physical examination, diagnostic tests,
treatment, certain minor surgical procedures, etc., all under the responsible
supervision of a licensed physician
Medex (Mx) [Fr. médecin extension extension of the
physician] : a program that recruits former military medics for training
and practice as physician assistants
attending physician : a physician who attends a hospital at stated
times to visit the patients and give directions as to their treatment.
family physician : a medical specialist who plans and provides the
comprehensive primary health care of all members of a family, regardless
of age or sex, on a continuing basis.
resident physician / resident : a graduate and licensed physician
receiving training in a specialty in a hospital
attending staff : the corps of attending physicians and surgeons
of a hospital.
consulting staff : the corps of physicians and surgeons attached
to a hospital who do not visit regularly, but may be consulted by members
of the attending staff.
house staff : the resident physicians and surgeons of a hospital.
specialism : limitation of practice or study to a particular branch
of medicine or surgery.
specialization : in medicine, medical practice limited to some special
branch of medicine or surgery.
specialist : a physician whose practice is limited to a particular
branch of medicine or surgery, especially one who, by virtue of advanced
training, is certified by a specialty board as being qualified to so limit
his practice.
fee-splitting : the division of moneys received by a specialist,
such as a surgeon, between himself and the physician who referred the patient
to him
intensivist : a physician who specializes in the provision of care
in the intensive care unit
nurse : 1. a person who is especially prepared
in the scientific basis of nursing and who meets certain prescribed standards
of education and clinical competence. 2. to provide services that
are essential to or helpful in the promotion, maintenance, and restoration
of health and well-being
hospital nurse : one employed by a hospital.
monthly nurse : a nurse who attends confinement cases.
practical nurse : a person who has had practical experience in nursing
care but who is not a graduate of any kind of nursing school; not to be
confused with a licensed practical nurse.
nurse practitioner, see n. clinician.
private duty or special nurse : one who attends an individual patient,
usually on a fee-for-service basis, and who may specialize in a specific
class of diseases; called also special n.
probationer nurse : a person who has entered a school of nursing
and is under observation to determine her fitness for the nursing profession;
applied principally to nursing students enrolled in hospital schools of
nursing.
student nurse : a person enrolled in a basic program of nursing
education.
graduate or trained nurse : a graduate of a school of nursing; often
used to designate one who has not been registered or licensed to practice
licensed practical nurse : a graduate of a school of practical nursing
whose qualifications have been examined by a state board of nursing and
who has been legally authorized to practice as a licensed practical or
vocational nurse (L.P.N. or L.V.N.), under the supervision of a physician
or registered nurse.
registered nurse (RN) : a graduate nurse who has been legally authorized
(registered) to practice after examination by a state board of nurse examiners
or similar regulatory authority
clinical nurse specialist : a registered nurse with a high degree
of knowledge, skill, and competence in a specialized area of nursing. These
skills are made directly available through the provision of nursing care
to clients and are indirectly available through guidance and planning of
care with other nursing personnel. Clinical nurse specialists hold a master's
degree in nursing, preferably with an emphasis in clinical nursing
nurse clinician : a registered nurse, referred to as a nurse clinician
or as a nurse practitioner, who has well-developed competencies in utilizing
a broad range of cues. These cues are used for prescribing and implementing
both direct and indirect nursing care and for articulating nursing therapies
with other planned therapies. Nurse clinicians demonstrate expertise in
nursing practice and ensure ongoing development of expertise through clinical
experience and continuing education. Generally, minimal preparation for
this role is the baccalaureate degree.
general duty nurse : a registered nurse, usually one who has not
undergone training beyond the basic nursing program, who sees to the general
nursing care of patients in a hospital or other health agency.
occupational health nurse : an especially prepared registered nurse
employed by an institution to apply nursing principles and procedures for
the promotion, restoration, and maintenance of optimal health of its employees
as compared to a nurse who performs normal nursing functions in an occupational
setting.
office nurse : a registered nurse employed by a physician in his
office to perform or to assist him in the performance of certain procedures.
community or public health nurse / visiting nurse : an especially
prepared registered nurse employed in a community agency to safeguard the
health of persons in the community, giving care to the sick in their homes,
promoting health and well-being by teaching families how to keep well,
and assisting in programs for the prevention of disease
district or community nurse : the name given in Great Britain to
a public health nurse, from the fact that such a nurse was placed in charge
of each one of the districts into which the city or community was divided
Queen's nurse : in Great Britain, a district nurse who has been
trained at or in accordance with the regulations of the Queen Victoria
Jubilee Institute for Nurses.
school nurse : an especially prepared registered nurse employed
in a school system or public health agency to assist in safeguarding the
health of students and to teach health practices.
scrub nurse : one who directly assists the surgeon in the operating
room.
special nurse : 1. a private nurse. 2. a nurse who specializes
in a particular class of cases.
wet nurse : a woman who breast-feeds the infant of another.
Nursing shortages have become a permanent feature of many health systems
and developed nations are increasingly dependent on overseas workers to
help solve the shortages. But nurse poaching depletes poor nations of much-needed
staff and leaves few incentives for rich countries to try to retain their
native workersref.
midwife : an individual who practices midwifery
certifiednurse-midwife (CNM) : an individual educated in
the 2 disciplines of nursing and midwifery, who possesses evidence of certification
according to the requirements of the American College of Nurse-Midwives
midwifery : the practice of assisting in
childbirth.
nurse-midwifery : the independent management of care of essentially
normal newborns and women, antepartally, intrapartally, postpartally, and/or
gynecologically, occurring within a health care system which provides for
medical consultation, collaborative management, or referral, and is in
accord with the functions, standards, and qualifications as defined by
the American College of Nurse-Midwives.
nursing : the provision, at various levels of preparation, of services
that are essential to or helpful in the promotion, maintenance, and restoration
of health and well-being or in the prevention of illness, as of infants,
of the sick and injured, or of others for any reason unable to provide
such services for themselves. Sometimes designated according to the age
of the patients being cared for (e.g., pediatric or geriatric nursing),
or their particular health problems (e.g., gynecologic, medical, obstetrical,
orthopedic, psychiatric, surgical, urological nursing, or the like), or
the setting in which the services are provided (e.g., office, school, or
occupational health nursing)
paramedical : having some connection with
or relation to the science or practice of medicine; adjunctive to the practice
of medicine in the maintenance or restoration of health and normal functioning.
Paramedical workers include physical, occupational, and speech therapists,
medical social workers, pharmacists, technicians, and so on.
practice : the utilization of one's knowledge in a particular profession,
the practice of medicine being the exercise of one's knowledge in the practical
recognition and treatment of disease.
contract practice : the treatment of the members of a specified
group for a lump sum, or at so much per member.
family practice : the medical specialty concerned with the planning
and provision of the comprehensive primary health care of all members of
a family, regardless of age or sex, on a continuing basis.
general practice : the provision of comprehensive medical care as
a continuing responsibility regardless of age of the patient or presence
of a condition that may temporarily require the services of a specialist.
solo practice : the provision of care by a single, self-employed
physician or dentist assisted only by auxiliary personnel
group medicine : the practice of medicine by a group of physicians,
usually representing various specialties, who are associated together for
the cooperative diagnosis, treatment, and prevention of disease
hospital (see also nosocomial
infections)
: an institution for the treatment of the sick. “An institution suitably
located, constructed, organized, managed and personneled, to supply, scientifically,
economically, efficiently and unhindered, all or any recognized part of
the complex requirements for the prevention, diagnosis, and treatment of
physical, mental, and the medical aspect of social ills; with functioning
facilities for training new workers in the many special professional, technical
and economic fields essential to the discharge of its proper functions;
and with adequate contacts with physicians, other hospitals, medical schools
and all accredited health agencies engaged in the better health program.”—Council
on Medical Education (CME)
care / treatment : the services rendered by members of the health
professions for the benefit of a patient
palliative care or treatment :
primary care : the care a patient receives
at first contact with the health care system, usually involving coordination
of care and continuity over time
secondary care : treatment by specialists
to whom a patient has been referred by primary care providers.
tertiary care : treatment given in a
health care center that includes highly trained specialists and often advanced
technology
respiratory care or therapy : 1. the health care profession providing,
under a physician's supervision, diagnostic evaluation, therapy, monitoring,
and rehabilitation of patients with cardiopulmonary disorders. 2.
a general term for the type of medical care provided by the members of
this profession 3. the diagnostic and therapeutic use of medical gases
and their administering apparatus, environmental control systems, humidification,
aerosols, medications, ventilatory support, bronchopulmonary drainage,
pulmonary rehabilitation, cardiopulmonary resuscitation, and airway management.
Called also inhalation therapy.
coronary care unit : a specially
designed and equipped hospital area containing a small number of private
rooms, with all facilities necessary for constant observation and possible
emergency treatment of patients with severe heart disease.
intensive care unit (ICU) /
intensive therapy room : a hospital unit in which are concentrated
special equipment and skilled personnel for the care of seriously ill patients
requiring immediate and continuous attention
room : an enclosed place in a building, set apart for specific purposes
such as the performance of procedures.
operating room : a room in a hospital equipped and used for surgical
operations.
recovery room : a hospital unit adjoining operating or delivery
rooms, with special equipment and personnel for the care of postoperative
or postpartum patients until they may safely be returned to general nursing
care in their own rooms or wards.
delivery room : a hospital room to which an obstetrical patient
is taken for delivery.
labor or predelivery room : a hospital room where an obstetric patient
remains during the first stage of labor, i.e., from the time the pains
begin until she is ready for delivery; called also labor r.
postdelivery room : a recovery room for the care of obstetric patients
immediately after delivery.
rooming-in : the practice of keeping a newly born infant in a crib
near the mother's bed, instead of in a nursery, during the hospital stay.
nursery : the department in a hospital where newborn infants are
cared for.
day care nursery : an institution devoted to the care of young children
during the day.
crèche : a day nursery for infants
base hospital : a hospital unit within the line of communication
of a branch of the armed forces, usually in a permanent building, designed
for the reception of wounded and other patients received via field hospitals
from the battle front, and for cases originating within the line of communication
itself.
camp hospital : an immobile military unit organized and equipped
for the care of the sick and wounded in camp in order to allow continued
mobility of field hospitals or other mobile sanitary organizations.
closed staff hospital : a hospital in which only members of the
staff are permitted to treat patients.
cottage hospital : a hospital consisting of a number of detached
buildings.
evacuation hospital : a mobile advance hospital unit within the
line of communication, designed to take over the functions of field hospitals
when they move away with their divisions and to supplement base hospitals
in their functions.
field hospital : a portable military hospital, manned by noncommissioned
officers and men, located beyond the zone of conflict, 3–4 miles beyond
the dressing stations, designed to shelter and care for wounded brought
in by ambulance companies until they can be transported to the line of
communications.
health promoting hospital
(HPH)
lying-in or maternity hospital : an institution for the care of
obstetric patients.
open hospital : 1. a mental hospital, or section of a hospital,
without locked doors or other forms of physical restraint. 2. a hospital
to which physicians who are not staff members may send their own patients
and supervise their treatment.
teaching hospital : one that allocates a substantial part of its
resources to conduct, in its own name or in association with a college
or university, formal educational programs or courses of instruction that
lead to granting of recognized certificates, diplomas, degrees, or other
documents required for professional certification or licensure.
voluntary hospital : a private, not-for-profit hospital; one of
the major purposes of voluntary hospitals is the provision of uncompensated
care to the poor.
partial hospitalization : a psychiatric treatment program for patients
who do not need full-time hospitalization, involving a special facility
or an arrangement within a hospital setting to which the patient may come
for treatment during the day and return home at night (day hospital
or
day surgery); or return at night after a day in the community to receive
treatment during the evening and to remain all night (night hospital);
or return at the end of the week to receive treatment and remain all weekend,
resuming his normal activities during the week (weekend hospital).
lazaretto : 1. a hospital for contagious diseases. 2. a quarantine
station.
sanitarium : an institution for the promotion of health. The word
was originally coined to designate the institution established by the Seventh
Day Adventists at Battle Creek, Michigan, to distinguish it from institutions
providing care for mental or tuberculous patients.
health maintenance organization (HMO) : a broad term encompassing
a variety of health care delivery systems utilizing group practice and
providing alternatives to the fee-for-service private practice of medicine
and allied health professions. They are essentially prepaid, organized
systems for providing comprehensive health care within a geographic area
to all persons under contract and they emphasize preventive medicine.
infirmary : a hospital or place where sick or infirm persons are
maintained or treated; commonly used to denote a space or a building set
aside for the care of members of a group or community; a dispensary
hospice : a facility that provides palliative
and supportive care for terminally ill patients and their families, either
directly or on a consulting basis.
learning
mnemonics : the cultivation or improvement
of memory by special methods or techniques
hypnopedia : sleep learning; learning during
sleep, as by listening to recordings.
medical mnemonics
MedicalMnemonics.com : a
free, non-profit, online searchable database of medical mnemonics to help
remember the important details.
Medical Antiques.com : the
internet resource for collecting medical, surgical, apothecary, dental,
and bloodletting antiques
braille [Louis Braille, a French teacher of
the blind, 1809–1852] : a system of writing and printing for the blind
by means of tangible points or dots. Blinded by an accident in his early
childhood, 15 year old Louis Braille (1809-1852) invented a system of reading
and writing by touch. A Braille cell consists of 6 raised dots. By arranging
the dots in various combinations, 64 different patterns cam be formed.
Braille, a true alphabet, is read by moving the hand from left to right
along each line. Readers average about 104-125 words per minute. Some can
read 250 words by using both hands.
disparities in drug and vaccine
development for diseases that mainly affect the developing world, as
opposed to those that affect industrialised nations. From the time of introduction
of a new vaccine in Europe or the USA, the adoption of these vaccines in
developing countries takes a decade or more. For example, hepatitis B vaccine
and Haemophilus influenzae type b conjugate vaccines have been used
routinely for over 10 years in North America and in most European countries,
with very successful control of disease, but although these vaccines have
also proven highly effective in developing countries, vaccine uptake has
mostly been slow. Several factors have contributed to this situation, such
as insufficient information on local disease burden, and questions of programme
feasibility. However, the main reason is that the poorest countries cannot
afford to purchase the vaccines. In 2001, three vaccine manufacturers developed
group C meningococcal conjugate vaccines in response to public health concerns
in the UK, where there had been about 10,000 cases of group C meningococcal
disease and 1,000 deaths during the previous decade. By contrast, no manufacturer
was interested in developing a group A meningococcal conjugate vaccine
for prevention of meningococcal disease in sub-Saharan Africa where, during
the same period, there were more than 700,000 cases and 100,000 deaths.
For virtually all diseases that largely affect poor countries, choice of
drug and vaccine development is market driven, and is not based on disease
burden or mortality.
transgenic soya was found in 10 of 25 organic or health food products on
sale in the United Kingdom. 8 of the 10 were labelled either as 'organic',
which should indicate the absence of transgenic ingredients under Soil
Association rules, or explicitly as 'GM-free'. Soya is a very popular
ingredient, both in organic and non-organic foods. Over 60% of processed
food in a typical supermarket contains soya extracts, including vegetarian
sausages and soya mince. Soya flour and unprocessed soya beans are also
popular in organic and health food shops. In addition, organic meat must
come from animals fed on organic crops, and many farmers use organic soya
meal as feed. The Soil Association, which employs some of the most rigorous
tests used by the 16 organisations licensed to hand out "organic" labels
in the United Kingdom, sets the upper limit for GM material in organic
foods at 0.1%, as it is technically difficult to measure contamination
at levels below this. But Murphy's paper reveals that at least one product
labelled by the Soil Association - an organic soya flour - contained slightly
more than the allowed 0.1% of transgenic soya. Other products, such as
vegetarian sausage, had up to 0.7% GM content. Almost all the soya from
the USA and Argentina, two of the world's major producers, is transgenic.
The world's third largest soya producer - Brazil - legalised GM varieties
of the crop last September. In many countries, GM-free crops are often
mixed with transgenic varieties after harvesting. And batches of soya seed
sold as non-GM can contain 1-2% from transgenic varieties.
The European Patent Office on May 18
2004 revoked a controversial patent on a breast cancer gene, which it issued
to the US company Myriad Genetics
in January 2001. The patent gave Myriad exclusive rights to any exploitation
of the BRCA1
gene sequence, including diagnostics in breast and ovarian cancer. Twenty
health institutions throughout Europe opposed the patent, arguing that
rights to a human gene should not be owned by a private company. However
the office revoked the patent only after opponents convinced it that Myriad
was not the first to register the correct gene sequence
biopiracy
Greenpeace says the variety of wheat patented by Monsanto, the world's
largest genetically modified (GM) seed company, possesses genetic characteristics
originally derived from a strain known as Nap Hal used to make chapatis,
the flat bread traditional to northern India. Nap Hal has less gluten than
other wheat varieties, which gives it lower viscoelasticity, meaning it
expands less during baking. This makes it perfect for crisp breads such
as chapatis. Unilever obtained Nap Hal seeds from public seed banks and
bred a variety dubbed Galatea from it. Monsanto acquired Galatea when it
bought Unilever in 1998. The European Patent Office granted patent number
EP445929,
November 9, 1991 for the strain last May. The Unite States had issued
Unilever
patents regarding low-viscoelasticity wheat strains : US Patent Number
5,763,741, June 9, 1998 and 5,859,315, January 12, 1999. Greenpeace
filed legal opposition to the patent at the European Patent Office
on January 27, with the support of the India-based Research
Foundation for Science, Technology and Ecology and the Indian farmers'
organization Bharat Krishak Samaj. "The technical features of the plants
described in the patent are typical of seed which is grown normally and
not allowed to be patented,” the opposition stated. “The patent owners
have not added anything new to what is state of the art; they have merely
described known features of wheat plants in such a way that they are supposed
to look as if they are new.” The activists added that “keeping the patent
would mean illegal monopolization of important genetic plant resources,”
and could block cultivation of all related varieties. While the patent
applies in 13 European countries as well as Japan, Australia, Canada and
the United States, it was not granted in India. This means Monsanto would
not have control over their new variety there, McDermott said. But the
company has not commercialized Galatea, and Monsanto is planning to exit
the wheat business in Europe.
fake medicines : in Lagos, they are called gbogbo n’ises, which
means “they can cure all ailments with one drug.” In Abidjan, Côte
d’Ivoire, and other parts of francophone Africa, they are known as pharmacies
par terre (roadside pharmacies). They are referred to as “chemists” in
Makola, Ghana’s biggest market, and they are very conspicuous as you arrive
at the City Market in Nairobi. In Lomé, Togo, they are more than
“pharmacists”; they are known as docteurs de rues (street doctors), because
they go beyond selling drugs. They diagnose, prescribe, and even advise
families to bring their patients to a given address if the symptoms persist.
These “doctors” and “pharmacists” claim to cure such ailments as malaria,
tuberculosis, sexual impotence, mental illness, infertility, and HIV/AIDS.
In most cases, they prescribe one drug that, according to them, is capable
of curing all those maladies
intelligent design hypothesis
: the idea that the origin of information is best explained by an act of
intelligence rather than a strictly materialistic processref.
Some consider it an evolved form of creationism that resulted from legal
decisions in the 1980s ruling that creationism can't be taught in schools.
Perhaps surprisingly, many theologians are equally upset by intelligent
design. "The basic problem that I have theologically is that God's activity
in the world should be hidden," says George Murphy, a Lutheran theologian,
PhD physicist, and author of The Cosmos in the Light of the Cross. Murphy
says Lutherans believe that God's primary revelation came through Jesus
Christ, and many find it distasteful that additional divine fingerprints
should appear in nature. Catholics, for their part, have accepted evolution
based on the idea that God could still infuse the natural human form with
a soul at some point in the distant past. And even the evangelical Christians
who make up the backbone of intelligent design's political supporters sometimes
object to its inability to prove whether Christianity is the true religionref.
baraminology : a term introduced in 1990, views biological creation
as happening instantly, rather than through evolutionary descent.
Views of US teenagers (aged 13-17) :
"Just your opinion, do you think that Charles Darwin's theory of evolution
is..."
a scientific theory that has been weel supported by evidences (37%)
just one of the many theories and one that has not been well supported
by evidence (30%)
you don't know enough about it to say (33%)
"Which of the following statements comes closest to your views on the origin
and development of human beings ?"
human beings have developed over millions of years from less advanced forms
of life, but God guided this process (43%)
God created human beings pretty much in their present form at one time
within the last 10,000 years or so (38%)
human beings have developed over millions of years from less advanced forms
of life, but God has no part in this process (18%)
Support for Darwin increases with level of education : % of adults who
believe evolution is a scientific theory well supported by the evidence
:
research biologists were puzzled by the fact that a wide range of ultimately
related properties, such as aortal surface area in warm-blooded animals,
and trunks or stems in plants, ranged in line with a fourth, rather than
a third, power law. This latter law was established in 1932. This long-awaited
explanation of why biology scales in four rather than three dimensions
emerged during the late 1990sref
and subsequent papers from this team showed that their theory is applicable
to all life forms: analyses of data sets taken over a long period did not
provide irrefutable evidence for 3/4 power scalingref. Practical
applications of these laws are emerging. Examples include determination
of correct drug doses for humans based on trials on smaller animals, and
acreage needs of animals of all sizes in the wild
in biology, the principal group of power laws relates a variety of fundamental
properties to the mass, M, of the organism. Now M varies
in line with the organism's volume and therefore as the cube of linear
dimensions such as height. At first sight, it would seem that other geometrically
based properties such as aorta diameter--and, in turn, functions such as
metabolic rate (the rate at which each cell produces energy) that depend
on these properties--should scale in line with the organism's volume as
some third-power law. But instead, they scale in various forms of a fourth-power
law, as if the organism's mass were a function of 4 rather than 3 linear
dimensionsref. The oldest and best-known power relationship
is Kleiber's lawref, devised by Swiss-American zoologist Max
Kleiber in 1932. It states that the metabolic rate of individual cells
scales as M-1/4 so that the metabolic capacity of a whole
organism (calculated by multiplying the total number of cells by the average
metabolic rate of each cell) scales as M3/4. If cellular
metabolic rate were a function of the organism's volume, this would scale
as M-1/3 and the total metabolic capacity as M2/3.
The 1997 paper derived the quarter-power laws from the hydrodynamics and
fractal geometry of the organism's branching network, in this case the
blood circulation of mammals, that delivers resources to an organism's
cells. Resources enter the blood stream via surfaces--the gut lining for
nutrients and water, and the alveoli of the lungs for oxygen. The key point,
and source of the fourth dimension, is the fact that the terminating units
through which resources pass into the blood stream, and out into cells,
are of fixed size independent of the mammal. Larger mammals just have more
of them. Therefore, the area of exchange between each terminating unit
remains the same. So, an organism's total area of exchange depends on the
total number of these invariant terminating units, and these are packed
into a volume, such as the lung or the gut's epithelial lining. The total
area of resource exchange, comprising all the invariant terminating units,
therefore scales in three dimensions. But the average distance the blood
travels to take resources from the source exchange point, such as the lung,
to the destination cell, also increases with the organism's size, but in
a single dimension. The total blood volume is then a product of the terminating
unit's total area, which scales in three dimensions, and the average distance
between source and destination, which scales in one. The result is a quantity
that varies in 4 dimensions, but which also must range in line with the
organism's mass if the ratio of blood volume to total tissue is to remain
constant. This does not immediately yield the precise quarter-power scaling,
but the relationships follow from consideration of the dynamics of branching,
subject to the principle that natural selection evolves efficiently by
transferring resources to the blood stream and then distributing it. The
theory of the quarter-power law has turned out to apply even more widely
than its pioneers expected. It was not clear whether quarter-power scaling
applied to such a wide range of phenomena--metabolic rate, aortal diameter--that
the underlying theory had to be generalized. Consequently, the work led
to a flurry of experiments and measurements showing that these quarter-power
scaling laws were more ubiquitous than almost anyone expected.4 Kleiber's
law scales from the largest to the smallest mammal, that is, from blue
whales to shrews, which covers about 6 orders of magnitude of mass, with
the same applicable to birds. But it is now known through their work and
others that Kleiber's law scales right down to unicellular organisms, increasing
the span of mass-magnitude order to 20, and it also applies to cold-blooded
creatures, plants and trees with exactly the same power law exponent of
3/4. Even within the respiratory complex of mitochondria, West et al. found
the metabolic rate to scale as a 3/4 power of mass.2,3 This extends the
range of Kleiber's law to 27 orders of mass magnitude, from large trees
or blue whales down to individual metabolic components at the molecular
level. In effect, Kleiber's law now embraces almost all biological processes
relying on distribution of metabolic resources, such as unicellular organisms
and even the mitochondria within them. Kleiber's law scales from the largest
to the smallest mammal, namely the blue whale to the shrew, which covers
about six orders of magnitude of mass. This development created a new theoretical
problem, because some of the systems now embraced by the power laws did
not have anything resembling a fractal branching network, which is a branching
set of connections that looks the same at different scales. This led Brown,
West, and Enquist to generalize their theory to any hierarchical form of
distribution in which resources are transported from a central location
to all points of the system--that is, the network fills the system's space,
whether this is a mammalian body or a single cell.2 The West/Brown/Enquist
theory still leans heavily on fractal geometry, even though it is now applied
in a virtual sense to networks that may not have any physical branches
at all, such as a cell's vesicles. As pointed out earlier, some physicists,
including Banavar, are unhappy that the theory must rely on the assumption
that resource distribution is based on a branching hierarchy, whether virtual
or not, in which supply lines divide progressively into smaller and smaller
tributaries. Some argue that the laws should apply for any network that
transmits resources from sources to destinations, subject to a few fundamental
constraints, such as tissue density and cell size being the same for all
organisms (for example, mammals) within a group. But for most biologists
the point is that the case for power laws now has been established beyond
all reasonable doubt. The challenge is to apply them in their research.
The quarter-power laws apply equally on the scale of ecosystems, which
can be regarded as resource distribution networks serving the fauna within
them. Brown is working to exploit the power laws to develop a complete
"Metabolic Theory of Ecology," which could be used for predictive modeling
of ecosystems based on three key variables: size, temperature, and availability
of critical resources. Size of the body determines the rate at which you
can supply resources to an animal. The second thing is the temperature
of the bath, which means environmental temperature, except for birds and
mammals. These two variables, size and temperature, account for most, but
not all, of the variations in a wide range of phenomena, from growth rates
and life-span, to rates of molecular evolution, to rates of speciation
and extinction, and the rates at which ecological interactions come in.
The effects of temperature are determined by Stefan Boltzmann's law, equating
chemical reaction time to e-E/KT, where e, again, is the natural
logarithm base, E is the potential reaction energy dependent upon the nature
of the reaction ingredients, T the absolute temperature of the environment,
and K Boltzmann's constant. The temperature law is well known, but Brown
has been studying the predominant cause of the remaining ecological variation--resource
availability. As oxygen and CO2 are ubiquitous, the primary
resources that can run short are water (over land), phosphorus for nucleic
acids, and nitrogen for protein. A shortage of any of these reduces an
ecosystem's productivity, but the question was by how much and whether
any precise scaling rule analogous to the quarter-power law could be derived.
The early evidence, says Brown, suggests that ecosystem productivity scales
with water according to a one-to-one linear relationship. That still needs
to be worked on, but it appears there is a linear scaling with water at
least. That means that where water is an issue, halving its availability
will halve the biomass of the ecosystem. If this is correct, then ecosystem
productivity varies, with mass according to the quarter-power law, with
temperature according to Boltzmann's Law, and with resource availability
according to a simple linear relationship. But for warm-blooded animals,
which have constant body temperature, the only relevant scaling is the
quarter-power law of size, assuming there is no resource shortage. At first
sight of the South African tropical savanna, there sometimes appear to
be insufficient resources for the existing species within a particular
habitat. Large species and small species view the world at a different
scale, so that the bigger you get, the more detail you omit. This opens
up opportunities for smaller species to have the leftovers of the larger
ones. This finding may seem obvious, but the power law makes it possible
to quantify the relationship between species and habitat sizes. Bigger
species have a disproportionate need for area, greater than you would expect
from their size alone. This has obvious implications for conservationists
attempting to maximize the protection for species given constraints over
available land area. Spanish Catchfly was once considered rare because
of its narrow distribution. Deptford Pink, despite its wider distribution,
is actually more rare. Power laws make such predictions possible. Another
notable ecological application of power laws is in determining how vulnerable
a rare species is to extinction. Put simply, a plant can be numerically
rare, but common in the sense that it is found in many different locations,
or it can be abundant in just one small spot. The more abundant plant might
then be more vulnerable to extinction through a single event, such as building
on its only habitat. This is an extreme example, but something similar
happening in the United Kingdom with 2 varieties of carnation, the Deptford
Pink and the Spanish Catchfly. Only the latter was listed as rare, on the
grounds that it was found within only about 6 adjacent 10 km2
grids within one region, East Anglia. The Deptford Pink was deemed more
common because it had been spotted in about 16 cells scattered across the
whole country. But the Spanish Catchfly was more abundant, by a factor
of 200, because of its greater density within the 10 km grids. So, by replotting
the occurrence of the two plants at a scale of 100 m2 grids
rather than 10 km grids, the relative rarities would be reversed. It all
depends on how closely one looks. The relevance here is that plant distribution
ranges with grid size according to a rule closely resembling a quarter-power
law, with a slight deviation resulting from other factors. The big prize
is that the power law makes it possible to predict with some degree of
accuracy how a plant variety is distributed in detail at a fine level of
resolution by considering sparse data at a coarser level, which is easier
to obtain. If that follows a power law, or indeed any other coherent relationship,
then looking at these relatively coarse scale things, you should be able
to make some sort of prediction about what's happening at finer scales.
The same principle should apply to animals as well as plants, although
complicated by seasonal and random migration. Power laws also have potentially
highly valuable applications at the level of single organisms, for example,
in the pharmaceutical industry. For years, researchers have used rats to
test new drugs, with dosage levels then scaled up to humans on the basis
of a linear mass relationship. This leads to overdosage if the decline
in cellular metabolic rate with size is not taken into account. The situation
is complicated further by the fact that some drugs, such as local anesthetics,
act in a small area, in which case the effective organism size is the immediate
region of the injection. Drug companies are now showing interest in this
potential application of power laws.
Meanwhile, the underlying mathematical debate relating to the 3/4 power
scaling law remains to be settled, with the quest being to circumvent fractal
geometry and develop a general scaling theory that holds for any resource
network that delivers materials within some structure. But such a theory
must also embrace the wide variety of biological phenomena that obey the
3/4 law.
Jacques Benveniste, who gave the world the 'memory of water', died
in Paris on 3 October 2004. His talk of witch-hunts, scientific priesthoods,
heresies and 'Galileo-style prosecutions' played well with those inclined
to regard science as an arrogant, modern-day Inquisition. He conjured up
images of a conservative orthodoxy, whose acolytes were scandalized by
a ground-breaking discovery that demolished their dogmatic certaintiesref.
He was, he suggested, a Newton challenging a petty-minded, mechanistic
cartesianismref.
Back in 1988, however, Benveniste was very much part of the establishment.
He was the senior director of the French medical research organization
INSERM's Unit 200, in Clamart, which studied the immunology of allergy
and inflammationref.
That was when he sent his notorious paper to Natureref.
In it, he reported that basophils can be activated to produce an immune
response by solutions of antibodies that have been diluted so far that
they contain none of these biomolecules at all. A talk he delivered last
June was a blinding blizzard of histograms. It was as though the water
molecules somehow retained a memory of the antibodies that they had previously
been in contact with, so that a biological effect remained when the antibodies
were no longer present. This, it seemed, validated the claims made for
highly diluted homeopathic medicines. After a lengthy review process, in
which the referees insisted on seeing evidence that the effect could be
duplicated in 3 other independent laboratories, Nature published the paper.
The editor, John Maddox, prefaced it with an editorial comment entitled
'When to believe the unbelievable'ref,
which admitted: "There is no objective explanation of these observations."
Naturally, the paper caused a sensation. "Homeopathy finds scientific support,"
claimed Newsweek. But no one, including Benveniste, gave much attention
to the critical question of how such a 'memory' effect could be produced.
The paper itself offered only the suggestion, at face value almost meaningless,
that "Water could act as a 'template' for the [antibody] molecule, for
example by an infinite hydrogen-bonded network, or electric and magnetic
fields." The idea that water molecules, connected by hydrogen bonds that
last for only about a picosecond (10-12 seconds) before breaking
and reforming, could somehow cluster into long-lived mimics of the antibody
seemed absurd. Other teams were subsequently unable to repeat the effect,
and the independent results that the reviewers had asked for were never
published. Further experiments carried out by Benveniste's team, in double-blind
conditions overseen by Maddox, magician and pseudo-science debunker James
Randi and fraud investigator Walter Stewart, failed to verify the original
resultsref.
The Nature paper was never retracted, but Maddox subsequently commented,
"My own conviction is that it remains to be shown there is a phenomenon
to be explained"ref.
Benveniste was unmoved by the wave of scepticism, even derision, that greeted
his claims. At DigiBio, the Paris-based
company he set up in the wake of the controversy, he devised another explanation
for his strange results. Biomolecules, he said, communicate with their
receptor molecules by sending out low-frequency electromagnetic signals,
which the receptors pick up like radios tuned to a specific wavelength.
Benveniste claimed that he was able to record these signals digitally,
and that by playing them back to cells in the absence of the molecules
themselves he could reproduce their biochemical effect, including triggering
a defence response in neutrophils, which kill invading cellsref.
The questions this raises are, of course, endless. Why, if this is the
way biomolecules work, do they bother with shape complementarity at all?
(When I asked Benveniste this, he said something about audio earpieces
being shaped to fit the ear.) How could a molecule act as an antenna for
electromagnetic wavelengths of several kilometres? And how does the memory
of water fit into all of this? Benveniste proposes that transmission of
the signal somehow involves the 'quantum-coherent domains' proposed in
a paperref
that now seems to be invoked whenever water's 'weirdness' is at issue -
for example, to explain cold fusion. The details were not, Benveniste said,
his responsibility. He was an immunologist, not a physicist. But his failure
to simplify his experimental system so that he could clarify the precise
nature of the effects he claimed to see, or the mechanisms behind them,
fell short of rigorous science. Benveniste could surely have tested his
radio-transmission theory at the level of simple, cell-free molecular systems.
I have found no evidence that he ever devised such experiments: he stayed
at the level of cells, tissues or whole organisms, where direct cause-and-effect
is hard to track and statistical tests are needed to cope with the significant
responses from control samples. The talk that he and his co-workers deliver
in June 2004 was a blinding blizzard of histograms. There can be no doubt
that Benveniste was genuinely convinced he had chanced upon something revolutionary.
It is a shame that he became isolated (he may have played a part in that),
which meant that genuine enquiry into his curious findings was hampered
by posturing on all sides. But the fact that it is the 'memory of water',
not 'digital biology', that he will be remembered for illustrates a point
that I think Jacques failed to appreciate: his work tapped into a potent
and persistent cultural myth about the miraculous properties of water.
And under the influence of myth, it can be hard to keep a level head.
a handful of clued-up individuals can steer a swarm of honeybees or a school
of fish in the right direction, research suggests. The finding could help
engineers to deploy robots more effectively in the future. A computer algorithm
has shown that animals with simple behaviour can use simple rules to make
complex group decisions. And as the group becomes larger, the proportion
of individuals who need to know what they are doing falls. The algorithm
gives its virtual animals several rules of thumb. One is that they try
to avoid becoming cut off from the crowd. Wild animals try to avoid this
too : a herring will die from stress if it is isolated from its school.
Another rule is that group members should avoid getting so close that they
crash into one another. In addition to these opposing forces, the virtual
animals are given a power of persuasion that depends on their desire to
lead the group in a specific direction. Completely naive animals, with
no idea of where to go, have zero power. The simulations show that even
when naive and informed individuals cannot recognize one another, the novices
spontaneously respond to decisions by the experts, because they follow
their tendency to stick with the group. More surprisingly, the computer
simulations reveal that as a group grows larger, it requires a smaller
percentage of leaders. Researchers already know that a few individuals,
perhaps 5% of the total, can guide a honeybee swarm. And the simulations
show that a larger proportion isn't necessary: this model explains how
that kind of complex information transfer can occur without requiring individual
cognitive complexityref.
The findings could help engineers design protocols to guide groups of robots
operating beyond human control, such as in outer space or the deep sea.
Robots could use simple collective decision-making to travel wisely in
dangerous environments. To see how well the findings apply to animals with
more sophisticated cognition, the researchers have begun to study human
crowds. They hope it will help to explain how people behave during evacuation
procedures. But the model may not apply directly to more complex animals
the 30-MB genome of Phanerochaete
chrysosporium strain RP78 contains 11,777 protein-coding genes,
including secreted oxidases, peroxidases, and hydrolytic enzymes that cooperate
in wood decay. The white rot fungi are the only microbes known to efficiently
degrade all the components of wood, including lignin, the most significant
aromatic polymer on Earth. Only a handful of organisms are able to degrade
lignin, so they're believed to be pivotal to the carbon cycle. P.chrysosporium
is also used extensively in industry, for instance, for the bleaching of
pulp from paper and textiles and the degradation of an array of organo-pollutants.
While other filamentous fungi respond to chemical stimuli with coordinated
expression of groups of genes, P.chrysosporium individually regulates
individual enzyme component
alimentary microbiology
assistive technology has dramatically
changed opportunities for students with disabilities : scientific research
can be tricky at the best of times, but people with disabilities face additional
challenges both in the lab and when dealing with data.
IVEO — one of the newest assistive technologies for the blind.
screen readers : softwares that convert what is displayed on a computer
screen into either audio or a Braille output that can be read on a special
keyboard.
1990 Americans with Disabilities Act
WinTriangle, produced by Gardner's Science Access Project, allows
a blind user to write mathematical equations, perform calculations and
hear mathematical text. In its simplest form it is a scientific word processor
with a specialized set of fonts representing symbols and operations that
can be read by a speech synthesizer. At Harvard University in Boston, Massachusetts,
physicists write papers using a typesetting language called LaTeX, so David
Thompson, a fellow student, wrote a software program to convert LaTeX into
WinTriangle. WinTriangle is 'open-source' software, which lets users adapt
and rewrite it to meet their needs. It is fairly common for assistive technologies
to be modified or enhanced by their users. Gardner recently teamed up with
Victor Wong, James Ferwerda and Ankur Moitra at Cornell University in Ithaca,
New York, who have developed software that translates colour pixels on
a computer screen into piano notes. The group hopes to combine the audio
software with IVEO's tactile technology to solve a particularly challenging
information problem.
touch-sensitive tablet to explore 3D images with a 'wireless' electronic
pen. "When you move the pen around on the tablet it's the same as looking
around on the screen. When using the tablet, Wong finds the pen is almost
too sensitive — it is actually better than the naked eye and gives too
much detail. In addition, there is no easy way to uncover the major features
of an image without tedious, pixel-by-pixel exploration. This is where
Gardner comes in. By combining IVEO's ability to display tactile maps with
the Cornell team's software for converting colour into sound, users will
be able to determine the boundaries of a map or graph more easily. Widespread
use of these technologies requires both money and cultural adjustments
: the latter is the hardest to achieve. Counsellors and teachers at all
levels, from preschool through to the very critical high-school years,
do not believe that students with disabilities can persist and excel in
science and engineering fields. One reason is there aren't enough role
models. In addition, few students, counsellors, teachers or employers know
about assistive technologies. And for some people, such technology doesn't
yet go quite far enough : this may be reflected in the low number of disabled
researchers. In 2000, the NSF estimated that 365,500 people with disabilities
were employed in science, technology, engineering and mathematics (STEM)
in the United States — about 7% of the science workforce. But there are
more people with disabilities in the general workforce (13%), and even
the college-educated workforce (9%). There is a strong under-representation
of persons with disabilities in STEM fields, especially at the PhD level
Griffin Shield : a navigation and communication system for motorized
wheelchairs and scooters : a small video camera is attached to the rear
of thewheelchair and an LCD monitor to the front. In effect, this is an
electronic 'rear-view mirror', powered by the chair's battery, which can
also be hooked up to a laptop for communication purposes
deep-sea exploration
human-operated vehicles (HOVs)
Alvin,
introduced in 1964, could dive to 4,500 metres : it has had a long and
venerable career, playing a central role in collecting data for around
1,800 scientific papers of research teams across the globe. Alvin's most
famous moment came in the late 1970s. While surveying Pacific Ocean ridges
researchers found a whole ecosystem that was based not on energy from the
sun, but on chemical energy from volcanic vents.
remotely-operated vehicles (ROVs), operated through a cable from
the support ship. 10-kilometre rings of plankton, fish clad in gooey coats,
and dozens of species of squid - these are all part of a newly uncovered
treasure trove of life in the deep. The Norwegian-led expedition, called
MAR-ECO, journeyed to the mid-Atlantic Ridge and spent two months sampling
the oceans to a depth of 4 kilometres. The 60-strong research team made
some staggering and unexpected discoveries. Among the 300 fish species
found was Aphyonus gelatinosus, a rare translucent bottom-dweller
that covers itself in a gelatinous layer. The team also spotted around
50 species of squid and octopus, and untold plankton and corals.The plankton
were marshalled by shifting currents into huge rings some 10 kilometres
across. But perhaps most intriguing was the scientists' discovery of evenly
spaced burrows in perfectly straight lines on a rocky outcrop 2,000 metres
down. The researchers believe they were made by a crustacean, but are at
a loss to explain how they were created in such a straight line, remarking
that the holes look as if they were made by a giant sewing machine.
autonomous underwater vehicles (AUVs) which make their own way through
the oceans.
a yet unnamed $23-million vehicle completed in 2008 will be capable of
diving to 6,500 metres, giving it access to 99% of the sea floor, including
the Cayman ridge in the Atlantic Ocean, which is about 5,000 metres deep.
A variable ballast system will allow the vehicle to work at multiple depths
during a single dive and a fibre-optic cable connected to a floating transmitter
to send data back to a support ship. This will enable the sub to transmit
information to the surface much faster than any existing deep-sea sub,
giving teams of scientists on the support ship or elsewhere real-time access
to the data and the chance to influence the work being done by the sub.
skyscrapers : the Freedom Tower
is to be the centrepiece of the rebuilt New York site and was originally
designed by architect Daniel Liebeskind. It should reach 541 metres
and scoop the crown for the world’s tallest building from the current record
holder, the 508-metre Taipei 101 tower in Taiwan. But Manhattan
is unlikely to hold the accolade for long, if at all. A residential tower
called the Burj Dubai, already germinating in the Arab Emirates,
is designed to top out at comfortably over 610 metres in 2008. Although
it temporarily dented confidence in the world’s tallest buildings, the
World Trade Center’s on September 11, 2001 collapse has not had a huge
impact on the structure of these future towers. Many believe the building
fell not because of flaws in its design but because of the intense heat
caused by the burning jet fuel. And experts say that expecting skyscrapers
to be able to withstand the onslaught of a jet plane is impractical, if
not impossible. Instead, the focus is on being able to evacuate thousands
of people quickly and safely in the event of a disaster, with some new
designs factoring in more escape routes, security measures and fire-resistant
building materials. Meanwhile, advances in technology are changing some
of the ways that architects and engineers reach for the clouds. Most existing
towers support the enormous weight of their 70 or more storeys through
a rigid skeleton of vertical steel columns, and sometimes a sturdy concrete
core in the heart of the building. But today’s skyscraper engineers are
experimenting with new materials. The Burj Dubai, for example, will use
super-strong concrete reinforced with materials such as microsilica, which
fills the gaps between other particles and makes for a more rigid support.
Super-tall buildings must also withstand the fierce winds that are present
at altitude. These create small vortices, which can generate uncomfortable
or even dangerous vibrations. To avoid this, architects often try to break
up the outline of a building: hence the tapered 452-metre Petronas towers
in Kuala Lumpur, Malaysia. Sophisticated computer modelling and wind
tunnels are likely to allow architects to experiment with even more flamboyant
designs in future. Engineers are also reaching for fresh solutions to deal
with the mind-boggling logistics of moving large numbers of people and
goods into and around such buildings, such as elevators that move both
vertically and horizontally, and to make the buildings more environmentally
friendly. Plans for the Freedom Tower include an array of wind turbines
on the roof. Solar cells and naturally lit atriums are on the cards in
other buildings. So how high will skyscrapers go? Technology is unlikely
to be the limiting factor : today’s building methods would allow engineers
to reach far beyond any current plans; perhaps as high as 1,600 metres,
except for the huge banks of elevators that would be required and the ear-popping
pressure changes that those riding in them would be subjected to. Ultimately
the heights we reach will be determined the egos and wealth of those behind
the projects.
scientists are not doing enough to make sure that that information is getting
out of the lab to those who can use it, a meeting of environmental scientists
in Washington DC heard this week. For example, scientists knew about December
2004 Indian Ocean earthquake within minutes of it happening. Yet no formal
alert was sounded and the resultant tsunami killed hundreds of thousands.
All 3 links of the warning chain were weak: the monitoring system in the
Indian Ocean wasn't good enough; there were no communication channels to
local authorities; and the public was not educated. And compared with establishing
lines of communication and teaching the populace to run for high ground,
setting up a few buoys is the easy part, speakers told the conference of
the National Council for Science and
the Environment on Thursday 3 Feb 2005. Too many times in the past
the researcher kept all his work in a filing cabinet somewhere and you
didn't get your hands on it until he was dead. But large projects such
as the Global Earth Observation System
of Systems (GEOSS) and Washington-based National
Ecological Observatory Network (NEON) are now trying to tailor their
data to the needs of the non-scientists who might use it. These might include
land managers, policy-makers and disaster workers. The environmental-forecasting
community should make their data as compelling and well publicized as the
Mars Rover photographs : how come the Earth doesn't get any respect? Younger
scientists are being trained in communicating science to the public and
see it as a rewarding part of their job
Many people love pearls for their soft, delicate beauty. But some engineers
admire mother-of-pearl / nacre—the substance of which pearls are
made—for its brute strength. Evolution has designed it over ages to protect
soft-bodied creatures such as sea snails. Now, researchers are trying to
steal nature’s secret by investigating the material’s structure at scales
not much bigger than the width of an atom. They’re hoping to use what they
learn to develop better armor for soldiers, airplanes and cars. Mother-of-pearl
forms the inner layer of shells of mollusks, shelled ocean invertebrates
such as snails and clams. The nanoscale is where the material’s structure
and properties set the foundation for its overall behavior, and its complexity
at this level is “quite amazing. Nacre is composed of 2 relatively weak
materials: 95% calcium carbonate, a brittle ceramic, and 5% a more flexible
material made of chains of molecules, called a biopolymer. These materials
are organized into a “brick-and-mortar” structure with millions of ceramic
plates, each a few mm in size, stacked on top
of each other like rolls of coins. Each layer of plates is glued together
by thin layers of the biopolymer. Nacre’s toughness results from the way
the materials are combined at different size scales. Even though the calcium
carbonate is very weak and brittle on its own, one can get enormous increases
in toughness this way. Replacing the weak building blocks of nacre with
stronger materials—in a similar design—has the potential to yield much
tougher composites for use in armor systems or structural applications
like automobile panels or plane wings. The team imaged the tiny plates
cut from the nacre of Trochus niloticus, a sea snail, using an atomic
force microscope.
Each plate was divided like a pie into separate sectors, with cylindrical
beams running through the thickness of the plates, and a fine surface of
bumps, called nanoasperities, which were further organized into
groups. Biopolymer molecules crossed over and bound to the array of bumps.
The researchers then used a diamond-probe tip a few hundred nm in size
to push into a plate while measuring the resistance it offered : the tablets
were both extremely stiff and strong at these length scales. The team is
now studying the forces that glue the plates and biopolymer together, as
well as the properties of a single biopolymer molecule. Nature uses nanoscale
structural design principles to produce materials with superior mechanical
properties. In many aspects, human engineers have yet to achieve the same
skill. However, as nanotechnology methods advance, the creation of artificial
nacre—and other kinds of high-performance armors—is becoming a more and
more realistic goal. (Ortiz C, Journal of Materials Research)
in both written text and speech, the frequency with which different words
are used follows a striking pattern. In the 1930s, American social scientist
George Kingsley Zipf discovered that if he ranked words in literary texts
according to the number of times they appeared, a word's rank was roughly
proportional to the inverse of its frequency. In other words, a graph of
one plotted against the other appeared as a straight line. The economist
and sociologist Herbert Simon later offered an explanation for this mathematical
relationship. He argued that as a text progresses, it creates a meaningful
context within which words that have been used already are more likely
to appear than other, random words. Piano and jazz usic pieces show a text-like
distribution, especially for the higher-ranking notes, but the strength
of the relationship varies. Although all of the piano pieces have a text-like
property, the atonal composition has less structure and less context; it
is like a story whose characters are constantly changing. The finding implies
that the reason many people find it unsatisfying to listen to atonal music
is not simply because its harmonic and melodic structures are unfamiliar,
but because the meaning or context of the piece is constantly changingref
French composers such as Edward Elgar
and Claude
Debussy. The researchers avoided modern composers, because they would
probably have been exposed to a range of cultures and languages. Whereas
previous work has compared the range of different pitches in languages
and their associated music, Patel and his colleagues looked at the size
of the jumps from note to note (how variable the intervals between pitches
were, not just how variable the pitches were). The intervals in French
speech and music turned out to be considerably less variable than their
English counterparts. In other words, classical concerts and café
chatter may sound rather smoother in Paris than in London. English language
and music both contain more rhythmic variation than the corresponding French
formsref.
Together, the rhythm and melody results make a strong case that language
significantly affects composers. This work suggests that people internalize
those patterns and express them in their music : understanding the patterns
in music can help to illuminate the statistical models our brains use to
digest language. Native Mandarin speakers are nearly 9 times more likely
to have perfect pitch
is appreciation of music a uniquely human trait, or does any animal with
decent hearing prefer pleasant combinations of notes? Cotton-top tamarin
monkeys, a species of squirrel-sized primates, have no taste for the consonant
tones that mostly make up music, suggesting that musicality may be restricted
to humans alone. Consonant tones are combinations of sound waves whose
wavelengths are simple multiples of each other. The sounds overlap to create
a smooth waveform that is pleasing to our ears. But dissonant sounds are
produced when the wavelengths are very slightly different, so the 2 waves
come in and out of phase, creating an unpleasant, jarring noise. For years,
scientists have sought to explain why we prefer consonant sounds to dissonant
ones. One theory is that our dislike of dissonance is related to the sensation
of 'beats' that occur when the notes interfere. Previous research has shown
that macaque monkeys and songbirds can tell the difference between consonant
and dissonant soundsref.
But the question of whether or not animals actually prefer consonant tones
has been unanswered, until now. The researchers put the tamarins into a
chamber shaped in a horizontal V. They played different types of sounds
in either end of the chamber, and judged which the monkeys preferred based
on the amount of time they spent on each side. McDermott and Hauser tested
their set-up by running 2 preliminary experiments. In the first, opposite
sides of the chamber played soft and loud white noise (static). The second
test contrasted feeding chirps and tamarin distress calls. The cotton-top
tamarins clearly favoured the softer white noise and feeding chirps, as
one would expect. Next, the scientists tested whether the monkeys found
consonant sounds more agreeable than clashing notes. But the animals spent
equal amounts of time on the both sides of the chamber. In contrast, the
humans tested by McDermott and Hauser showed a distinct liking for consonant
soundsref.
More closely related primates, such as chimpanzees, might still share some
sort of musical appreciation with people. But he speculates that rather
than being a result of the mammalian auditory system, our enjoyment of
consonant, musical tones derives from specifically human properties of
our brains.This research supports the idea that humans have a special preference
for consonance, one of the most basic structural elements of music : this
could account for the fact that as far as we know, only humans produce
songs simply for enjoyment
Britain is in harmony with Europe, Nordic countries fancy each others'
stars, and France is out on a limb. That's the verdict of a group of physicists
who have studied the much loved and loathed Eurovision
Song Contest. This annual event pits musical groups from each of 20
or so European countries against one another in an orgy of kitsch costumes,
unique dance routines and songs with titles such as Diggi-Loo Diggi-Ley.
To non-Europeans it might seem a puzzling and even vaguely disturbing cultural
phenomenon. But to the contestants, it is serious stuff. In 1974 Eurovision
shot the Swedish group Abba to international fame when their song Waterloo
triumphed. The 2005 contest, held in Kiev on 21 May and marking the event's
50th anniversary, will be broadcast to an audience approaching 1 billion
people. But the significance of the Eurovision Song Contest goes deeper
than music : it is a barometer of European nations' feelings about their
neighbours, and thus as a testing ground for compatibility as the creation
of a European constitution looms. In the contest, each country performs
a song, which is awarded points by all the others; the one that gathers
the most points overall is the winner. The system sparks bitter accusations
of reciprocal voting: for example, some accuse the Scandinavian states
of favouring each other. Others think that the votes reflect traditional
antipathies between adjoining countries, meaning the Dutch won't vote for
the Belgians. This is arguably the only major international forum in which
a given country can express its opinion about another, free of economic
or governmental bias. They argue that a systematic pattern in voting can
be revealing and have analysed vote networks between 1992 and 2003. Each
country represents a point in the network, and links between them are forged
when one country awards points to another. Statistically, these networks
turn out to be far from random: some countries form cliques that tend to
vote in the same way and for each other. This is most evident for Greece
and Cyprus, but the Nordic countries also tend to operate a block vote.
Geographical proximity doesn't guarantee harmony, however: Spain generally
doesn't vote the same way as Portugal. The Eurovision Song Contest is an
example of an international marketplace in which players repeatedly exchange
goods. In this case the goods are votes, but they could equally well be
ideas, opinions, money or food. They claim to have found a measure of how
close each nation feels to the rest of Europe. And to their surprise, it
seems that Britain is the most 'European', despite the fact that it is
an island. France, which is often thought of as a 'core' European state,
shows the least compatibility. Their analysis is based on one contentious
assumption: that all the songs presented are equally good, so that votes
are a reflection of national taste rather than the absolute quality of
the entries. However, for many aficionados, assessing the awfulness of
the entries is the whole pointref.
Australian researchers have delved deep into the world of acoustic physics
to unravel part of their country's indigenous heritage: the ancient art
of playing the didgeridoo.
The secret of an accomplished performance, they have discovered, is all
in the voice box. The didgeridoo, an aboriginal instrument also called
the yidaki, is traditionally made from a tree trunk hollowed out by termites.
It can produce a huge variety of different timbres, despite it usually
playing only a single note. This is because a skilled player alters the
acoustics inside the mouth to set up strong resonances at certain frequencies.
This alteration is done by moving the glottis, the part of the windpipe
that contains the vocal cords. This enhances certain frequencies while
inhibiting others, much as different vowel sounds are produced by adopting
different positions for the tongue and vocal cords. Skilled didgeridoo
players do this subconsciously : none of the players to whom we've spoken
is aware of it. But the creation of these characteristic frequency bands,
called formants, is what gives their playing expression and variety. The
researchers investigated the acoustics inside experienced players' mouths
by inserting a thin tube, about the size of a drinking straw, next to the
didgeridoo. They played a 'probe sound' made of a range of frequencies
through this tube and recorded the sound as it bounced back out, while
the player was performing. By analysing this recording for frequencies
that were impeded or enhanced during didgeridoo playing, the team investigated
the acoustic properties of the mouth and throat. Such studies are difficult
because they involve detecting the probe sound amid the noise of the didgeridoo's
drone. Sound levels inside the player's mouth can reach 100 decibels, which
is as loud as a chainsaw. Wolfe and his team discovered that formants are
produced when the player closes the glottis, which narrows the windpipe.
If the vocal tract remains fully open, as in normal breathing, the lungs
absorb much of the sound. So have they discovered a fast track to expert
didgeridoo playing? It will still take practice to emulate the most sophisticated
players, not least because skilled playing requires a mastery of circular
breathing. This involves maintaining the outward airflow through the mouth
by contracting the cheeks while breathing in through the nose. Try it and
you'll see how tricky it is... and that's before you start learning the
repertoire of different sounds. It's easy to make a basic sound. "Then
you have to learn circular breathing. Learning to make strong formants
takes a while. Other techniques involve vocalizing and playing at the same
time: one gets interactions between the vibrations from the lips and from
the vocal cordsref.
some of the tunes are catchy, some vaguely familiar, others like nothing
on Earth. There are more than a trillion trillion trillion of them, all
accessible at the click of a finger. When you listen to one of the compositions
created by WolframTones, an online
music resource devised by researchers at Wolfram Research, you are almost
certainly the first person ever to hear it. The tune is composed on the
spot by a computer program that draws on the patterns explored by British
mathematician Stephen Wolfram. The idea of using Wolfram's work to compose
music isn't unique. But the site is perhaps the first to make it so easy
to produce and listen to the musical creations; you can even download them
as ring tones for your phone. In 2002, Wolfram excited intrigue and controversy
when he published his book A New Kind of Science, a 1,000-page argument
for why algorithmic processes based on cellular automata underlie the basic
laws of physics. A cellular automaton model consists of a grid of cells
that can each adopt one of several states, such as a checkerboard on which
each square can be empty or occupied. The model evolves according to a
set of rules that describe how the state of each cell depends on that of
its neighbouring cells. Research has shown that automata can mimic natural
phenomena, from snowflakes to patterns on sea shells. Wolfram has suggested
that they form the basis of much more, including the fundamental physics
of the subatomic world. Of particular interest are automata in which the
rules lead to grid patterns that are constantly changing in a seemingly
organized way, and yet are not repetitive. A classic example of this is
the Game of Life
devised in the 1970s by British mathematician John Horton Conway. In this
program small clusters of 'live' cells seem to behave like coherent organisms,
moving around a computer screen eating up other clusters or spawning offspring.
Now Wolfram and computer scientist Peter Overmann have constructed a program
that converts an automaton to a musical score, assigning different pattern
elements to different notes and instruments. Like the corresponding visual
patterns, the scores (usually) have enough constancy to avoid descending
into chaos, but enough unpredictability to remain interesting. Others have
used aspects of Wolfram's early work on cellular automata to do something
similar. George Lewis, a professor of music at Columbia University in New
York, collaborated with experimental musician Joel Ryan in the mid-1980s
to create compositions this way. Brazilian composer Eduardo Reck Miranda
has even drawn on the Game of Life for his scores. What is different here
is that it is made easy for just about anyone to do it, which I like very
much. WolframTones produces compositions that last just 30 seconds. You
can select compositions from a range of conventional styles, from 'classical'
to 'country' and even 'experimental'. The program searches the automaton
soundscape to find patterns that match the typical features of such styles.
However, Overmann admits that this is a fairly subjective process. This
aping of conventional styles actually limits the musical merit of the approach.
All they're doing is modelling things on existing notions of how music
goes. But is it really music? People do seem to perceive what we have as
music. We've heard from many composers, both classical and pop, who want
to use WolframTones in their work. He is currently working with a composer
from the New England Conservatory, Boston, Massachusetts, to produce a
full-length composition that will be played by live performers. Wolfram
is equally interested in what this approach might teach us about music
perception. It's surprising, to me at least, the extent to which different
people seem to agree about which compositions they think sound good.
human activities shift 10 times as much material on the Earth's surface
as all natural geological processes put together. That's the conclusion
of geologist Bruce Wilkinson at the University of Michigan, who has used
the geological record to estimate the earth-moving capacity of natural
processes over the past half a billion yearsref.
Wilkinson was inspired to calculate a natural 'baseline' for the movement
of soil and sediment after reading a paper published in 2000ref.
Hooke called humans "geomorphic agents", comparing them to land-shaping
forces of nature, such as rivers, glaciers, rain and wind. He reconstructed
the history of human impact on the landscape from intentional ground-moving
processes such as excavation and mining, as well as unintentional effects
caused by erosion of cultivated land. This impact has been increasing exponentially
over the course of human civilization, and suggested that we have now become
arguably the premier geomorphic agent sculpting the landscape. There's
no argument about it: we are 10 times more active at land-shifting than
nature. The new results should help to settle an ongoing debate about the
effects of human activity on soil. When natural vegetation is cleared and
land is tilled for growing crops, the soil typically becomes more prone
to erosion by wind and rain. But some researchers have argued that, in
the USA at least, fresh soil is being formed as quickly as existing soil
is being eroded, or that, even if soil is being lost overall, it's not
happening quickly enough to cause a crisis. In the light of his comparison
with natural erosion rates, statement is difficult to substantiate. We're
losing agricultural land rapidly. According to one estimate, it takes 500
years for natural soil-forming processes to replace an inch of soil. Wilkinson
based his estimate of natural soil and sediment movement on the rate at
which sedimentary rocks have been formed over the past 500,000,000 years.
Taking into account that such rocks are also steadily destroyed as one
tectonic plate slides under another, on average the continents lose a few
tens of metres thickness of sediment every million years. In comparison,
human earthworks and agriculture lead to a current average loss rate of
about 360 metres per million years. That's enough material to fill the
Grand Canyon in about 50 years. And although the figure is rising exponentially,
it's not just in recent times that human activities have rivalled the effects
of nature : human-related erosion became equal to natural processes about
1,000 years ago. A large part of the problem is simply population growth.
Although modern agricultural techniques have led to a decline in the amount
of earth moved per person, the world's population is growing so rapidly
that this outweighs the effects of such improvements.
an international team of researchers has used particles called antineutrinos
that are produced in the bowels of the Earth to estimate how much of the
core's heat comes from natural radioactivity. This is the first time these
elusive particles have been used to study geology. Previous work on neutrinos
and their antimatter counterparts, antineutrinos, has been concerned with
fundamental physics and astrophysics. The results rely on measurements
of antineutrinos made at the Kamioka
liquid scintillator antineutrino detector (KamLAND), which is housed
in a mine underneath a mountain in central Japan. They establish neutrino
science as a way to look at the deep Earth. They may also help to solve
some long-standing mysteries about how hot our planet is at its core, and
how long it will take to cool. For the first time we can say that neutrinos
have a practical interest for other fields of science. The 87-strong team,
from Japan, the United States, China and France, say the results confirm
that about half of the heat inside the Earth comes from the decay of radioactive
elements that produces antineutrinosref.
The rest comes from processes in the planet's iron-rich core and from heat
left over from the Earth's fiery birth 4.5 billion years ago. This heat
plays a central role in the behaviour of the Earth. It causes convection
(the slow churning of sluggish rock in the planet's mantle), which in turn
drives the movements of tectonic plates at the Earth's surface. This drives
everything from mountain formation to earthquakes and volcanism. Much of
the interior of the Earth is still a mystery to scientists. "Essentially,
we only know the crust of our planet," says physicist Giorgio Gratta of
Stanford
University in California, a member of the KamLAND team. We can drill holes
a few kilometres deep, but beyond that, you simply don't have access. Most
of what is known comes from studying seismic tremors passing through the
planet. These can reveal boundaries between different kinds of rock. But
antineutrinos produced by radioactivity in the mantle can tell researchers
something about the chemistry down below. Antineutrinos have hardly any
mass, and barely interact with other matter at all, so they tend to pass
straight through the Earth. But they can be detected by KamLAND, where
flashes of light are triggered by occasional collisions between antineutrinos
and other particles in a 13-metre-wide tank filled with oil and benzene.
Despite counting antineutrinos for more than two years, the researchers
haven't yet spotted enough of them to make a very accurate measurement
of the heat produced by radioactivity. But they hope that this will improve
as they gather more data and combine them with those obtained from a similar
detector called Borexino in Italy, which is scheduled to begin operations
in 2006. Better data could ultimately revolutionize some areas of geoscience.
I'd like to see a more precise result, but this shows it can be done. With
several antineutrino detectors in operation, it should be possible to conduct
a kind of chemical tomography of the Earth, measuring how the radioactive
elements are distributed and therefore how uniform the mantle is. It's
a revolution, but these are very difficult measurements and the detectors
are very expensive. It will be 10 or 20 years before there are enough neutrino
detectors to obtain firm answers to geological questions.
in 'karst' landscapes soluble rocks dissolve to form cavities and channels.
Some of these become cave systems; others might be filled with water or
oil, creating aquifers and petroleum reservoirs below the Earth's surface.
Most karst systems are formed when carbonic acid, the product of CO2
dissolved in water, eats away at carbonate minerals. However, sulphuric
acid (a by-product of metabolism of hydrogen sulphide by bacteria forming
white mats coating the floor of the cave) can transform limestone (calcium
carbonate) into gypsum (calcium sulphate, which is very soluble in ground
water, and it dissolves, leaving behind a void that gradually grows bigger)
: the standard, wrong explanation was that hydrogen sulphide gas, from
the water of thermal springs, bubbled out into air-filled pockets and reacted
with oxygen to form the sulphuric acidref
molten rock pushed through the cracks between tectonic plates up to 10
times faster during the Early Cambrian than it does today. More cracks
in the rocks would allow more sea water to percolate through, dissolving
minerals from below the surface and then delivering enormous amounts of
extra calcium to the ocean. The amount of calcium in sea water shot up
between the end of the Proterozoic era (about 544 million years ago) and
the early Cambrian period (about 515 million years ago) and this could
have helped to drive the extraordinary diversification of species and body
shapes known as the Cambrian explosion : this change allowed soft-bodied
marine organisms to create hard shells or body parts made from insoluble
calcium minerals. Calcium carbonate is the main component of sea-shells
today, and is also used by microscopic sea creatures such as radiolarians
to make exquisitely patterned 'exoskeletons'. Although hard shells and
exoskeletons are generally regarded as defences that make soft organisms
hard for predators to eat and digest, some researchers think these mineral
shells might have originally served a different purpose. They may have
been simply a way for organisms to get rid of the calcium dissolved in
their tissues when its concentration became dangerously high. In other
words, the shells are a form of solid waste. The formation of mineral shells
might then have prompted organisms to become more diverse, making new body
shapes possible, fostering new designs in predators and helping to trigger
the Cambrian explosion. But not everyone thinks organisms have to be so
responsive to changes in their environment : after all, marine organisms
have sophisticated mechanisms for keeping their internal calcium concentrations
much lower than that of sea waterref
the 500-metre-high dunes in China's Badain Jaran desert remain standing
in the face of savage winds as they are held together by a previously undiscovered
groundwater system. Although the dunes are dry on the outside, water from
melting snow on Qilian Mountain, 500 kilometres to the southwest of the
desert, sticks the grains together just 20 cm below the surface, allowing
them to stand firm against the elements, despite the fact that the well
was 17 m above the level of one of the nearby lakes. It percolates through
cracks in the mountain and into layers of carbonate rock, eventually finding
its way into the dune system. The dunes are surrounded by 72 lakes, with
a total surface area of 23 km2. But nobody suspected that there
would be so much extra water inside the dunes themselves - the researchers
calculate that some 500 million m3 passes through the region
each year. Chinese authorities are planning a large water-diversion project
near Qilian Mountain, which would shift 250 million m3 of water
a year. That may now be unnecessary and taking water from the dunes could
cause them to move or break apart, with potentially severe effects on the
local ecosystemref
dating
Internet gives scientists methodologies for dating
intriguing differences between real-life romance and the virtual version.
In normal friendships and courting, for example, people tend to gravitate
towards their own type; like movie stars, popular folk hang out with other
well-liked friends or lovers. On pussokram,
however, well-connected people are less selective. This might be because
people feel freer to go for different kinds of romantic partners under
the cloak of anonymity. Ultimately, such analyses could reveal information
with a practical use. Marketers and political campaigners, for example,
are interested in finding out how to identify and target people with numerous
contacts (called hubs), who might spread the word about a product or candidate.
These people might also be more likely to pass on a sexually transmitted
disease, and so be targeted with public-health information. On pussokram,
it is hard to tell whether seemingly popular people actually end up with
more trysts in the outside worldref.
the vowel sounds in your name could influence how others judge the
attractiveness of your face according to a reasearch on hotornot.com.
For boys, a good name will contain vowel sounds made at the front of the
mouth, such as 'e' or 'i' sounds; names with fuller, rounder vowel sounds
such as 'u' tend to score lower. So pat yourself on the back if you're
called Ben... but if your name is Paul you might have to work harder to
snare a date. The opposite is true for girls, Perfors found. Women with
round-sounding names such as Laura tended to score higher than those with
smaller vowel sounds. Front-mouth vowels imply smallness, but when girls
are looking for mates, they don't necessarily want a super testosterone-charged
guy. They want someone who will hang around and be a provider. If you are
a good-looking person with a bad name you are still more attractive than
an unattractive person with a good name. the cultural connotations of a
name could influence how attractive people find those with such names.
She asked people to rate the 'masculinity' or 'femininity' of different
names, to see whether this affected subjects' scores on the website. Predictably,
guys with the names deemed most masculine tended to score highest. Names
were generally judged masculine because they contained strong consonants
such as 'b' and 'k'. But girls scored higher when they had either a very
feminine or a strongly masculine name; names judged to be somewhere in
the middle scored worst. The finding seems say that guys need a rugged
name to impress the ladies, whereas being a tomboy is cool for girls. Experts,
including the Swiss linguist Ferdinand de Saussure, have previously argued
that vowel sounds are arbitrary building blocks with no intrinsic meaning.
although it may never reach the market, a new type of dating tool could
give inspiration to the romantically challenged. By attaching electrodes
to regular eating utensils, inventor James Larsson has created knives and
forks that can pick up on whether the person across the table feels uncomfortable
or pleased, helping those who have difficulty reading signals such as body
language from their date. The device analyses data from the cutlery to
provide information about how their dinner companion is feeling. The system
relies on electrodes to measure the skin's resistance to electric charge,
like those used in lie detectors. When people feel suddenly stressed, their
skin's resistance plummets, partly because any sweat released under these
circumstances facilitates the movement of charge. Lie detectors have relied
on this phenomenon for decades, but only now have the sensors been brought
to the dinner table. When he started building the as-yet-nameless dating
device in 2001, Larrson originally aimed to make the system covert. In
the ideal setup, dates would not know that they held a special monitoring
device in their hands while eating, but lots of wires are currently needed
to connect the knife and fork to a computer monitor, so the technology
has not yet achieved this secrecy. And because dates must hold both utensils
to allow the small, stress-measuring current to run through their body,
the device does not work with when someone eats holding only a fork. Making
the electrodes work on cutlery was a challenge. Lie detectors are generally
used in a controlled environment where the subject sits still. But when
people eat, they constantly shift their fingers over the different electrodes
on the special utensils. And they apply varying pressure as they cut pieces
of food on their plate. To address the first problem, Larsson designed
specialized software on the machine to which the fork and knife relay information.
The program selects data from only those electrodes touching the hand at
a given time and ignores the ones without contact. He has also attached
strain gauges to the utensils. These run to the computer as well, preventing
the system from mistaking increased pressure as heightened stress. The
result is a computer that produces graphs to show when the person eating
felt uncomfortable and when they were more relaxed. Because the system
remains obvious, with all of its wires, it has yet to be used on a real
date. But Larsson has tested the device on himself during a lunch with
his mother. The graphs revealed that he felt stressed. The inventor readily
concedes that the system may not help any couples get together in the near
future. At the moment, its value is more playful. Hopefully there's a good
dollop of humour mixed in because that's what I intended
what exactly is it that makes overhearing others' mobile phone conversations
so annoying? You might imagine that it's simply a question of being
riled by loud voices spouting inane drivel about people we've never heard
of. But we also feel an innate need to listen when we can only hear one
side of a conversation. Even if it's no louder than a regular two-way exchange,
the fact that we can only hear half means that we instinctively tune in,
almost as if we're expecting to join in to complete the conversation. If
this idea is correct, the researchers reason, then mobile phone chatter
should be no more annoying than overheard conversations where both people
are present but only one voice is audible. People are fine if there seems
to be a purpose to the conversationref.
Passengers rated 2-sided exchanges as less noticeable than both kinds of
single-sided conversation. The team staged the one-sided face-to-face conversations
by ensuring that both volunteers walked past the victim before sitting
behind him or her, to establish that two people were present. On a train
there's a lot of background noise - it's not unusual that one person's
voice would be obscured. Bellowing voices are more irritating than
softly spoken onesref.
Another factor that makes mobiles annoying is the content of conversations.
Mobiles are still a relatively new invention and it will take time for
people to develop an agreed etiquette. As ever with new technologies, the
Japanese are leading the way. Polite mobile phone users in Japan tend to
turn away and shield their conversations from others. If that fails to
catch on, there's always the less genteel approach. Many theatres and train
companies are considering investing in jamming devices that will thwart
phone pests before they've even had a chance to assault us with their oh-so-catchy
ringtone.
April Fool's Day is one of the most
light hearted days of the year, yet it stems from a serious subject—the
adoption of a new calendar. Ancient cultures, including those as varied
as the Romans and the Hindus, celebrated New Year's Day on April 1. It
closely follows the vernal equinox (March 20th or March 21st.) In medieval
times, much of Europe celebrated March 25, the Feast of Annunciation, as
the beginning of the new year. In 1582, Pope Gregory XIII ordered a new
calendar (the Gregorian Calendar) to replace the old Julian Calendar. The
new calendar called for New Year's Day to be celebrated Jan. 1. Many countries,
however, resisted the change. In fact, some European countries held out
for centuries (Scotland until 1660; Germany, Denmark, and Norway until
1700; and England until 1752). In 1564 France adopted the reformed calendar
and shifted New Year's day to Jan. 1. However, many people either refused
to accept the new date, or did not learn about it, and continued to celebrate
New Year's Day April 1. Other people began to make fun of these traditionalists,
sending them on "fool's errands" or trying to trick them into believing
something false. The French came to call April 1 Poisson d'Avril, or "April
Fish." French children sometimes tape a picture of a fish on the back of
their schoolmates, crying "Poisson d'Avril" when the prank is discovered.
In 1752, Great Britain finally changed over to the Gregorian Calendar,
and April Fool's Day began to be celebrated in England and in the American
colonies. Pranks and jokes are of course still popular on this day—not
to mention the rest of the year.
in certain contests, candidates who take their turn at the end of a
sequence are consistently ranked higher than those at the beginning.
The bias is evident regardless of whether the judges score each contestant
immediately, or rank them all at the end. Most experiments in decision
science (a relatively new, interdisciplinary field that probes the mysteries
of how humans make choices) present all of the options to their subjects
simultaneously. But in the real world, when choosing an apartment or meeting
a stream of suitors, for example, one often sees the alternatives in sequence
: the judging of World and European Figure
Skating Championships which are scored step-by-step, with judges awarding
points to each skater directly after their routine, and the Eurovision
Song Contest, an annual jamboree in which European countries pit their
finest pop songs against one another, was studied. Before 1975, judges
handed out all the scores together at the end of the competition, but the
event's organizers have since switched to the more televisually dramatic
step-by-step method. Scores climbed as the competitions went on, with late-appearing
singers and skaters getting higher marks on average. Even those early Eurovision
judges who gave out marks to everyone at the end preferred later acts.
Score decisions nominally made at the end of the night may actually have
been made step-by-step in each judge's headref.
The reasons for this trend are still unclear. It may be due to 'direction
of comparison effects', which arise as judges focus heavily on the differences
between performersref.
If contestants are all of a high standard, as in the figure-skating championships,
any unique features will probably be considered positive, and the contestant
will seem better than previous ones. Of course, one might question whether
the Eurovision Song Contest is an event in which all the contestants are
of an impeccable standard. Although the positive unique features in each
performance may push scores up in skilled competitions, other situations
are rife with negative features, and so scores may well slide downhill
over the sequence. Scientists routinely present the options in their experiments
in various orders to factor out the effects of position, but speed-dating
is enough of a logistical effort without attempting to have everyone meet
each other again in a different order. From wine-tastings to the dating
game, the standard procedure is to assign positions in the sequence randomly.
But this doesn't eliminate bias, it merely applies the bias randomly
stone skipping has been a competitive
past time for thousands of years. The aim - to achieve the maximum number
of rebounds per throw - has remained unchanged since the time of the Ancient
Greeks. Jerdone Coleman-McGhee, who in 1992 skipped a stone 38 times on
the Blanco River in Texas, holds the world record. To achieve the maximum
number of rebounds, the angle between a spinning stone and the water should
be about 20°. Spin, speed and shape are also important. A stone is
more likely to rebound if it is rotating because spin stabilises the object
and prevents it from falling into the water. Speedy stones are more likely
to bounce than sluggish ones. A 5-cm disc approaching the water at the
magic angle needs to fly faster > 2.5 m/s in order to avoid taking a plunge.
Flat, round discs are ideal as their large surface area creates bounce
on impact. The system may help physicists who wish to model spacecraft
descent. As the Space Shuttle re-enters Earth's dense atmosphere, for example,
it also bounces much like a stoneref.
walking :
the porters of Nepal
are famous for being the most spectacular haulers of head-supported loads
in the world. They trek up and down steep mountain trails, sometimes for
hundreds of kilometres, while carrying goods in a basket supported by a
strap across their foreheads. Often the loads exceed the porter's own body
weight. Nepalis carry loads more economically than any other group previously
studiedref.
They expend less energy per load than both Westerners with backpacks and
African women who carry baskets on their heads, either directly or with
a strap. It is known that they usually walk with a slow pace and take frequent
breaks, sometimes resting for 45 seconds out of every minute on a steep
climb. But the porters are also efficient when walking at a steady pace.
Perhaps they alter their gait to somehow reduce muscular work, the researchers
guess, or in some other way increase their efficiency. A selection of porters
carrying their loads up to a weekly market at the town of Namche was asked
to walk around a flat track at various speeds while carrying several different
loads. The energy expended by these individuals was determined by measuring
their oxygen consumption and carbon dioxide production through a mask.
The team then compared the results with work on women of the African Kikuyu
and Luo tribes. These women can carry head loads of up to 20% of their
body weight without expending extra energy. Additionally, they carry loads
of up to 60% of their body weight at a considerably cheaper metabolic cost
than army recruits carrying equivalent backpack loadsref.
At light loads, the Nepalese porters and the African women were about equally
efficient. But the heavier the load, the better the Nepalese became at
expending minimal energy. The African women conserve energy by swinging
their bodies like a pendulumref.
But the Nepalese porters had a different gait. They didn't use the same
energy saving mechanism as the African women. The team plans to study this
next.
As Monty Python's John Cleese famously complained, silly walks just
don't get the support they deserve. But there is probably a good reason
for that: a mathematical model shows that the traditional styles of walking
and running really are the most efficient ways to get around. That's despite
the fact that both walking and running involve bouncing up and down. The
leading theory of locomotion holds that humans and other animals should
move in a way that minimizes the amount of energy they expend. So Ruina
and Srinivasan were intrigued to find out why all this jiggling is more
efficient than slinking along as smoothly as possible, like a waiter carrying
a tray of soup. The pair created a mathematical model that reduces locomotion
to its fundamentals: a certain mass, representing the body, that must be
moved around on two struts, the legs, that can absorb forces and expend
energy to shift the mass. They used the model to deduce the styles that
require the least effort to move a mass. Walking is best at slow speeds,
and running is the most efficient mode when moving in top gear. Although
other models have investigated the efficiency of walking and running before,
this is the first to work out the best means of locomotion from first principles.
It shows that the most energy-efficient way to move along is to bounce
up and down. The model also predicted a third efficient way of moving,
somewhere between running and walking. The style, dubbed 'pendular running',
is not generally used in the real world. It is as looking like an 80-year-old
trying to run. It's like a lumbering run, maybe for a fat or out-of-shape
person. When walking, each leg acts as a pendulum, swinging the body's
mass from leg to leg like an upside-down version of a monkey swinging from
branch to branch. As a result, each footfall generates two force peaks:
one as the foot lands, and another as it pushes off again. Walking is most
efficient at speeds where the body is moving slowly enough to be passed
smoothly from one pendulum to the other. This explains why walking is still
efficient even when though the body bobs up and down - this is simply a
product of the legs' natural pendular swing. When running, the foot acts
more like a ball, bouncing the body back up into the air in the same instant
that it lands. Each footfall therefore generates a single force peak. At
speeds where the body is going too fast to be transferred smoothly from
pendulum to pendulum, the most efficient method is to bounce it along in
a series of free-falling flights. Pendular running falls halfway between
the two. As in running, the two feet are never on the ground at the same
time. But each foot stays on the ground long enough to cause the double
force peak characteristic of walking. Perhaps the reason most of us don't
use this in the real world is simply because we don't need to. But some
people may benefit from the odd gait. Ruina notes that his model doesn't
take into account our legs' natural springiness, which would make bounce-running
even more efficient. But some people, such as those who are very heavy,
might lack this springiness. For them, a lolloping half-run might be the
most efficient way to travelref1,
ref2.
swimming in syrup : > 300 kilograms of guar gum (an edible thickening
agent found in salad dressings, ice cream and shampoo) was dumped into
a 25-metre swimming pool to create a gloopy liquid twice as thick as water.
Whatever strokes they used, the swimmers' times differed by < 4%, with
neither water nor syrup producing consistently faster times. Isaac Newton
and his contemporary Christiaan Huygens argued the toss over it back in
the 17th century while Newton was writing his Principia Mathematica,
which sets out many of the laws of physics. Newton thought that an object's
speed through a fluid would depend on its viscosity, whereas Huygens thought
it would not. In the end, Newton included both versions in his text. The
reason is that while you experience more "viscous drag" (basically friction
from your movement through the fluid) as the water gets thicker, you generate
more forwards force from every stroke. The 2 effects cancel each other
out. That's not always the case. Below a certain threshold of speed and
size, viscous drag becomes the dominant force, making gloopy fluids are
more difficult to swim through. Had you done this experiment on swimming
bacteria instead of humans, you would have recorded much slower times in
syrup than in water. But for humans, speed depends not on what you swim
in, but on what shape you are. Once the effects on thrust and friction
have been cancelled out, the predominant force that remains is 'form drag'.
This is due to the frontal area presented by a body - try running with
a large newspaper held in front of you and see how much more difficult
it is. So the perfect swimmer, whether in water or syrup, has powerful
muscles but a narrow frontal profile.
Are you reading this more than a day and a half after it was posted on
Nature's news site? If so, it's a fair bet that either you've unearthed
it from an archive or the article is unusually popular. A team of scientists
from Hungary and the USAs has found that the majority of online news
items have a lifetime of just 36 hoursref.
As reporters have always suspected, yesterday's news is stale, and the
day before's news is invisible. An analysis of hits on Origo,
Hungary's main online news and entertainment portal, probably applies not
only to other online news portals, such as this one, but also to other
websites on which new items are posted regularly, such as online markets.
The result could help news agencies to determine how much impact their
stories have, and how that depends on the online habits of their readers.
It has always been difficult to assess the lifetime and impact of newspaper
stories, because it is hard to monitor buyers' reading habits. But working
out which stories they read, and when, is easier for online sites that
can log the hits for each news item. In a single day the Origo portal released
3,908 news stories. On a typical day, Origo logs a total of 6,500,000 hits.
The researchers looked at the relationship between the number of hits per
item and the date the item was released, as well as the patterns of visits
to the site by individual users. Unsurprisingly, each item receives the
most visits on the day it is posted, and the number of hits falls off rapidly
after that. There is a daily rhythm because nearly all readers of the Hungarian
site are in Hungary, so hit patterns are not affected by having readers
in different time zones. After just 3 days, most people who are ever going
to read the item have already done so. Even with an archive, online reporters
cannot pretend they are writing for posterity. A typical user sees only
53% of the items before they disappear from the portal's main page, and
actually downloads only 7% of them. News outlets could improve those figures
by making story listings reactive, so that the most popular stories get
pushed to the top automatically. Of course, some news items do have lifetimes
much longer than the 36-hour average. Will this be one of them? Will it
have typical time history, or might it get picked up by popular blogs and
given a new lease of life? Nature will monitor its fate and reveal the
results in a week's time. Watch this space.
chess : in deciding which move to make, chess
players mentally map out the future consequences of each possible move,
often looking about eight moves ahead. Scoring the quality of the move
sequences by comparing them with Fritz 8, one of the most powerful
chess computer programs available, novices are more likely to convince
themselves that bad moves would work out in their favour, because they
focus more on the countermoves that would benefit their strategy while
ignoring those that lead to the downfall of their cherished hypotheses.
Conversely, masters tended to correctly predict when the eventual outcome
of a move would weaken their position. Grand masters think about what their
opponents will do much more, tending to falsify their own hypotheses. The
philosopher Karl Popper called this process of hypothesis testing 'falsification',
and thought that it was the best way to describe how science constantly
questions and refines itself. It is often held up as the principle that
separates scientific and non-scientific thinking, and the best way to test
a hypothesis. But cognitive research has shown that, in reality, many people
find falsification difficult. Until the latest study, scientists were the
only group of experts that had been shown to use falsification. And sociological
studies of scientists in action have revealed that even they spend a great
deal of their time searching for results that would bolster their theories.
Some philosophers of science have suggested that since there is so much
rivalry within science, individuals often rely on their peers to falsify
their theories for them. The behaviour may actually be widespread, but
it could be limited to those who are expert in their field. The ability
to falsify is somehow linked to the vast database of knowledge that experts
such as grand masters - or scientists - accumulate. People who know their
area are more likely to look for ways that things can go wrong for them.
It is unknown whether ther falsification skill of chess masters is transferable
in other activities that involve testing hypotheses - such as logic problems
art fakes : a technique, devised by computer
scientist Hany Farid and colleagues at Dartmouth College in Hanover, New
Hampshire, identifies the artist by analysing an individual's characteristic
brush or pen strokes. The method promises to reduce the subjectivity of
art assessments made by human experts. Such judgements are currently the
standard way of authenticating works of art, but they are known to be prone
to error. Very recently, a painting long thought to be an imitation of
the Dutch painter Jan Vermeer was found, after close scientific analysis
of the pigments and technique, to be most probably genuine. Technology
has been deployed in this field before. Some forgeries of famous artists
have been detected by chemical analysis of the pigments in the painting,
which have showed that some of the pigments were not available at the time
the work was allegedly painted. But this requires that tiny samples be
removed from the painting, which art conservators prefer to avoid. And
such methods are less useful for distinguishing genuine works from those
of an artist's pupils. During the Renaissance in particular, most famous
painters ran workshops in which apprentices learnt to paint in the style
of their master, and often completed parts of his works. In such cases,
attributions rely almost entirely on the evaluations of experts. The computer
technique devised by Farid and colleagues depends on the fact that, although
apprentices, imitators and forgers might be adept at copying the general
appearance and style of a particular artist, no one wields a paintbrush
or a pen in quite the same way as anyone else. Brush or pen strokes are
as individual as a person's handwriting. The researchers evaluate such
features of an image using a mathematical technique called wavelet analysis.
They scan a picture at high resolution and then use the wavelet technique
to decompose the picture into sets of vertical, horizontal and diagonal
lines. The art experts are always talking about the painter's lines : this
method makes maths out of the metaphor. From the mathematical distribution
of lines, the researchers calculate a set of numbers that characterizes
each picture. These numbers can be regarded as coordinates in a multi-dimensional
space, like a grid reference. If 2 images share similarities in their use
of line, the points in space defined by their coordinates will lie close
together, even if the scenes depicted are totally different. This allows
different painters to be distinguished. For a set of 13 genuine and imitation
Bruegel landscapes, the points corresponding to the 8 pictures deemed to
be authentic all sat together in a cluster, and the fakes were further
away. The method can be applied to different parts of a single painting
too. That is how Farid and colleagues deduced that 3 of the 6 faces in
Pietro Perugino's Madonna and child with saints were painted by
the same artist, perhaps Perugino himself, whereas each of the other faces
seemed to be by a different painter. This interpretation was corroborated
by art historians at Dartmouth College's Hood Museum, where the picture
is kept. This would never be the final word for authentication, but it
could provide the experts with a tool that augments and tests their evaluations.
Researchers in Japan have managed to carve tiny numbers and pictures
into a fingernail, in the form of microscopic dots burnt into the nail
by laser. The team has only managed the feat on nail clippings so far,
but they hope the process could one day be used to securely carry information
on live fingertips. It might even replace credit cards, they suggest, although
you'd have to get your information carved in every 6 months or so as the
nail grows out. Yoshio
Hayasaki of the University of Tokushima and colleagues say a single
fingernail could accommodate something like 800 kB of data. That won't
provide room for a high-resolution photo, but would be enough to store
basic identification information. Hayasaki and his team achieve the feat
by using a laser that delivers very short pulses of infrared light onto
a
finely focussed spotref.
The researchers think the energy unravels keratin molecules in the nail,
which makes the molecules more fluorescent. When the nail is illuminated
with blue laser light to excite fluorescence, recorded dots appear brighter
than the material surrounding them, allowing the information to be read
out under a microscope. Because it is possible to adjust the depth of the
writing laser's focal spot inside the nail, several layers of information
can be superimposed within a single slab. But writing and reading with
a live subject would be tricky, says the team, because the spots are just
3 mm across. Slight, involuntary movements of
the subject's finger during carving would ruin the effect. They are working
on a way to compensate for this movement. But, quite aside from the matter
of having to replenish the data every six months or so, there are some
substantial obstacles to turning the approach into a practical technology.
If your nail gets too warm, that could cause problems : heating can uncoil
keratin too. And the system might not be so secure. It would be very simple
to forge the information. You wouldn't need a lot of technology to do that.
Perhaps the system would be of more use to people who want to surreptitiously
move information from one place to another. So although credit cards are
unlikely to be replaced any time soon, spies and government agents may
prove customers for this technology.
holograms : graphologists are restricted
to looking at flat, 2D writing, and good forgeries can sometimes slip through
the net. Faked signatures are much easier to detect now there is a system
that can produce a 3D image of a handwriting sample. Pressure differences
in the pressure applied by the writer as they marked the page are extremely
difficult to mimic. 2 signatures made by the same person are never quite
identical. But the sequence of each pen stroke, and therefore the way that
the lines overlap, will always be the same. For example, the cross of a
't' is normally always made after the upright is drawn, and generally moves
from left to right. More subtle writing movements, which differ more between
individuals, are also highlighted by the system. Such movements include
whether a loop was drawn clockwise or anticlockwise. As someone signs his
or her name, the pen carves a microscopic furrow into the page. When one
line crosses another it makes a slightly deeper depression in the paper,
and also breaks down the walls of the first furrow. As the surface of the
paper is uneven, the LASER light reflects at slightly different angles
depending on where it strikes the furrows. This makes the light rays interfere,
forming patterns of light and dark on a light-sensitive device held above
the paper. The information is relayed to a computer, which constructs a
holographic image of the signature. The system can reveal characteristic
patterns for signatures that have been made with ballpoint pens, fountain
pens or felt-tipped pens on normal paper, cardboard or even carbon paper.
In almost 90% of the cases they tested, the author of a particular letter
could be identified by comparing details of how their pen strokes crossed
with a set of verified writing samples. For ballpoint pens on normal paper,
the success rate was 100%. The scientists say that the system could also
be used to study ancient documents that may be too precious to analyse
in other, potentially damaging ways. The equipment is rugged and portable,
and could be taken into museums to do analyses on site
detector trains are used by railway
companies to scan track. These probe the rail with ultrasound, revealing
cracks in the same way that ultrasound waves show a baby in the womb. But
most detector trains are limited to around 50 kilometres per hour, and
often disrupt passenger services. Even the fastest crack detectors - the
'Doctor Yellow' trains that patrol Japan's bullet-train lines at speeds
above 200 kilometres per hour - run at night and do not take paying passengers.
The new device also uses ultrasound but works at faster speeds than previous
models : it could therefore be fitted to ordinary trains without disrupting
journeys. Unlike conventional crack detectors, in which the ultrasound
generator touches the rail, Dixon's device uses a wire positioned several
millimetres above it. Electrical pulses in the wire set up currents in
the rail. These generate stresses that are released as ultrasound waves.
The waves reflected back to the device reveal cracks in the rail, and their
size. Dixon reckons that the invention could thus give an indication of
the severity of any damage. Efficient crack detection is the Holy Grail
of railway engineering : part of the problem is that cracks do not grow
steadily - they are born slowly, then expand quickly. This often means
that cracks go undetected until it is too late to repair them. Size matters
- the cracks we need to detect, we're only detecting with 10% accuracy.
Ultimately there is no substitute for looking at rails But Dixon hopes
that fitting as many trains as possible with crack detectors will highlight
previously undiscovered damage. Detecting cracks without disturbing schedules
could help ensure proper maintenance. In Britain, for example, different
companies own tracks and trains. Those responsible for crack detection
have to compensate train operators for disruption.
superfast trains of the future could
glide over fluffy tracks like snowboarders over snow. The same principle
could be used to develop low-friction, long-lived bearings for machinery
with moving parts. In snow, this lift is created by air between the tiny
ice crystals. When the snow is compressed by the weight of a board, the
air is pushed out from the porous snow, exerting an upwards pressure on
the board. This cushion of air means that there is very little friction
slowing the snowboarder's motion. The same forces allow red blood cells
to glide smoothly along our capillaries. A loose mesh of sugar-coated proteins
on the vessel walls gets squeezed by the passage of a red blood cell, pushing
out fluid from between the protein strands. To find out whether the forces
generated would be enough to support a whole train, the lift force created
when snow inside a cylinder is compressed by a piston, was measured. During
the first one and a half seconds or so of squeezing, there was a surge
in upwards pressure as air was pushed out of the porous snow. Within a
couple of seconds, this pressure dropped virtually to 0, as most of the
air had drained away. This is why light, fluffy snow can support the heavy
load of a snowboarder, provided that she doesn't linger for longer than
about a second. As long as the snowboarder keeps moving fast enough, she
won't sinkref.
Train carriages weighing up to 50 tons could skate over fluffy tracks without
sinking in. The track would consist of 2 side walls, filled by fluffy material
with the same bouncy properties as goose down. Goose down itself would
be too costly for filling miles of track; but there are plenty of synthetic
substitutes, like those used to fill cheap pillows. Because the train would
only be supported when travelling at high speed, the vehicles should have
retractable wheels that run along the track side walls when the train slows
down or as it gathers speed from a standing start.
It's official, says one group of researchers: Blade II is a bad
film. Their study turns patterns of attendance into a single number
that claims to grade a film's qualityref.
The number attempts to gauge of how good the 'word of mouth' was around
a given film, based on the behaviour of the harshest critics of all, the
paying public. The 'word of mouth' effect in the film world simply because
reviews often have a huge impact on audience numbers and there are copious
data on ticket sales. A mathematical equation approximates box-office takings
in the weeks after release. Revenue relies on 3 major factors: the size
of the possible audience, the initial desire of audience members to see
the film (which is often dictated by the amount spent on marketing and
publicity), and audience response to the film. The team then plugged arbitrary
numbers into their simple equation to create dozens of graphs describing
weekly box-office results for a film during its cinema lifetime. If the
marketing weighed in heavily, for example, but audience reviews were poor,
the resulting graph would peak in the first week and then plummet. If the
reviews were good, however, the graph would keep climbing. When they compared
their graphs with actual box-office data (available on the Internet
Movie Database (IMDb)) for 44 recent films, they found good matches
for films ranging from huge blockbusters to budget flicks. The review coefficient
(the word-of-mouth component of their equation) is a rough indicator of
the film's quality. The comedy Kissing Jessica Stein, for example,
can be modelled using a large, positive review coefficient. It started
with initially poor attendance, but increased its box-office take over
the following five weeks owing to good reports from the audience. In contrast,
Blade
II looks like a classic bomb: a large negative review coefficient matches
its quick dive in takings. It's a fun paper, but it's quite a basic model.
They don't consider a lot of the complications. The model could be improved
by factoring in the effect of a film's availability on its box-office take,
for example. Many people who would like to see a particular low-budget
film are unable to because it is not playing in a local cinema. Good quality
films don't always win financially, even if they do have more staying power.
A bigger initial interest in Blade II meant that its overall box-office
take was > 10 times greater than that of Kissing Jessica Stein,
which took just US$7 million in the USA. Big blockbusters are often simultaneously
distributed to > 3,000 cinemas in the USA, so a film generally does enough
business in its first two weeks to recoup its costs, which is the first
priority of the studio. However, about 70% of film revenue now comes from
outside the box office. The rise in home video and DVD sales, along with
toys and other products, means that pleasing the audience is ever more
important for a film's overall financial success. Thinking of films this
way should help studios to decide whether to commission a sequel. Even
high-grossing films can be deeply unpopular with the audience, which dooms
their cinematic offspring. If only they'd thought of that before commissioning
the third in the Blade series.
history
sound waves ricocheting around the tiered steps of the El Castillo pyramid,
at the Mayan ruin of Chichén
Itzá near Cancún in Mexico, create sounds that mimic
the chirp of a bird and the patter of raindrops, supporting a theory that
the ancient Mayans built their pyramids to act as giant resonators to produce
strange and evocative echoesref.
The bird-call effect, which resembles the warble of the Mexican quetzal
bird, a sacred animal in Mayan culture, was first recognized by California-based
acoustic engineer David Lubman in 1998. The 'chirp' can be triggered by
a handclap made at the base of the staircase. But did the pyramid's architects
know exactly what they were doing? Declercq's calculations show that, although
there is evidence that they engineered the pyramid to produce surprising
sounds, they probably couldn't have predicted exactly what they would resemble.
The precise sound caused by the echoes depends on the sound that excites
them. Drums, for example, might produce a different type of resonance.
Indeed, Declercq heard one such variation during the 2002 trip. As other
visitors tramped up the steps of the 24-metre high pyramid, he noticed
a flurry of pulse-like echoes that seemed to sound just like rain falling
into a bucket of water. Declercq wonders whether this, rather than the
quetzal call, could have been the aim of El Castillo's acoustic design
: the rain god played an important part in Mayan culture. But perhaps such
meaningful interpretations are fanciful. Declercq's team has shown that
the height and spacing of the pyramid's steps creates like an acoustic
filter that emphasizes some sound frequencies while suppressing others.
But more detailed calculations of the acoustics shows that the echo is
also influenced by other, more complex factors, such as the mix of frequencies
of the sound source. Ultimately, then, it will be virtually impossible
to prove that any specific echo effect is intentional. Similar effects
of the quetzal theory are produced produced by staircases at other religious
sites. At Kataragama in Sri Lanka, for example, a handclap by a staircase
leading down to the Menik Ganga river produces an echo in response that
resembles the quacking of ducks
the Battle of Marathon actually
happened on 12 August 490 BC, and not 12 September 490 BC. Legend has it
that after the battle ended, a runner was immediately dispatched to deliver
the good news to Athens, roughly 26 miles away: the world's first marathon.
Upon arrival the heroic messenger exclaimed, "Rejoice, we conquer!" and
promptly expired. Most historians, however, think that this part of the
tale is a myth. The summer heat of August may have pushed the runner into
a state of heat exhaustion, perhaps explaining his reported collapse.
the ancient Egyptians mummified millions of mammals, birds and reptiles.
The sheer number led many to believe that they were prepared with little
care compared with human mummies. It was assumed that they were simply
wrapped in coarse linen bandages and/or dipped in resin. But chemical analysis
found a plethora of organic substances, including beeswax, sugar gum and
plant resins and oils, which were all routinely used in human preservation.
Beeswax is antifungal and repels water, explains Evershed. Vegetable oils
would also have kept water out, whereas antimicrobial resins from conifer
and pistachio trees would have helped to prevent the bodies' decay. Sugar
gum was probably used to stick the bandages down. Traces of petroleum bitumen
were also found. This may have added to the waterproofing effect, but it
could also have been used to colour the mummies black. Black represented
life to the Ancient Egyptians. Ancient Egyptians treated animals with great
respect, regarding them as domestic pets and representatives of the gods.
The Greek historian Herodotus describes three grades of human mummification,
based on cost and complexity. The top class involved fully eviscerating
the body, desiccating the organs, and wrapping the corpse in treated bandages.
Previous, less sophisticated studies suggested that animals probably received
the second grade of treatment, in which their organs would have been treated
inside the body. But it's impossible to know exactly what went on, says
Evershed. Embalming was a secretive activity practised by trained professionals
behind closed doors. And the reports written by Herodotus post-date the
peak of Egyptian mummification, so it's hard to know how accurate they
areref.
the world's most expensive coffee, Kopi Luwak, which cost over US$1,000
a kilogram with an annual production < 230 kilograms : beans are
eaten and passed through the intestinal tract of the Asian palm civet (Paradoxurus
hermaphroditus) and picked up from faeces before being roasted
and savoured. A similar result can be obtained experimentally in Ethiopia
with African civets (Civettictis
civetta) : in both cases the civets' digestive action broke down
proteins in the beans into smaller molecules that added to the flavour
and aroma of the coffee on roasting. Some proteins were leached out of
the beans completely, making the resulting coffee less bitter : the guts
of the Indonesian civets did a much more thorough job of breaking down
the proteins than did the digestive systems of the African civets. The
slow passage through the bacteria and enzymes in the civet's gut is similar
to a method of fermenting coffee called the wet process, using the same
agent: lactic acid bacteria.
most shoppers acknowledge that when stores entice them in with festive
music and scents at Christmas time, they are encouraged to buy more.
But new research suggests that it may not be quite so simple. If shops
get the combination wrong, or don't make enough of a commitment to creating
a festive atmosphere, they may do more harm than good to their sales. The
effect of a store's atmosphere on shopping habits was largely ignored until
the early 1970s, when marketing guru Philip Kotler suggested that retailers
should use scientific methods to test what encourages shoppers to buy.
That may seem obvious to us today in a sensory-bombarded shopping culture,
but it wasn't back then. Now, shops try to appeal to all our senses, especially
during the holidays. Throughout the Christmas shopping season, they bombard
visitors with festive music, lighting, colours and smells. But creating
a holiday atmosphere still involves mostly guesswork. Most companies don't
scientifically control and explore these variables, they just follow their
instincts. To test the influence of holiday-themed music and scents, Spangenberg
and his colleagues asked 130 volunteers to look around a mock store, and
rate how attractive they found the merchandise on a scale of 1 to 7. As
they viewed different products, the researchers played one of 2 different
albums by pop musician Amy Grant. One included Christmas songs whereas
the other had no particular theme. At the same time, the volunteers were
exposed to either a background smell of evergreen trees and cinnamon, designed
to be reminiscent of Christmas, or to no fragrance at all. The Christmas
music and scent together made no difference to the volunteers' preferences.
They gave the merchandise an average score of 6.65 with the festive atmosphere,
compared to 6.69 with no Christmas influence. But if only one festive factor
was used, the shoppers' ratings fell. With only the Christmas music, the
merchandise scored on average 6.06, and with just the Christmas smell it
scored only 5.69. So why bother with holiday extras at all? Around this
time of year you need to as customers expect the shops to be festive. But
he warns store owners that if they are going for a Christmas theme, they
need to provide an all-round atmosphere, as half measures could leave people
confused. You've got to have all the pieces in effect at once. Muzak, a
leading supplier of music to businesses around the world, has picked up
on the power of combined smell and song. According to spokesman Sumter
Cox, Muzak has recently begun working with ScentAir, a company that makes
fragrances for use in shops. But it's unclear how many retailers will be
convinced by Spangenberg's work. For example, the creative minds behind
the holiday decorations at the British chain store Marks & Spencer
take their inspiration from foreign markets and landscapes, not scientific
equations, according to a spokeswomanref1,
ref2
As the slender white plane lifted off the Kansas airstrip, it marked the
start of a daring attempt to make the first solo, non-stop, non-refuelled
flight around the Earth. The plane, called GlobalFlyer,
lifted off at 0:50 GMT on 1 March 2005 and is designed to travel the 36,788
km required to circumnavigate the world in just 80 hours. It was built
by aviation pioneer Burt Rutan and his Californian company Scaled Composites,
and is piloted by balloonist and glider pilot Steve Fossett. From Salina,
Kansas, the craft will attempt to coast on the west-to-east jet stream
across the Atlantic. From there it will wing its way across North Africa
and the Gulf, then over India, China and Japan before cruising across the
Pacific and back into the USA. A last-minute route change means that Fossett
will not fly over Europe, owing to the prevailing winds shifting southwards.
GlobalFlyer is a successor to Rutan's aircraft Voyager, which in
1986 became the first plane to fly around the world non-stop carrying 2
passengers. The craft took 9 days to make the journey. The challenge
with a solo flight is to achieve the round-trip fast enough that the single
pilot can stay mostly awake for the whole trip. GlobalFlyer is a jet,
much faster than the propeller-driven Voyager, but Fossett will still have
to endure a 3-day journey. GlobalFlyer looks very different from most jets,
however, as it was created with one purpose in mind: to travel as far as
possible on as little fuel as possible. It is exceptionally aerodynamic
and light, and hence fuel-efficient. The body of the plane is built from
ultra-light composite materials such as graphite and epoxy, and the long,
narrow wings are sculpted to give maximum lift. GlobalFlyer also packs
fuel into every available space. It's a flying fuel tank. The plane was
a cumbersome beast when it lifted off, with fuel taking up > 80% of its
9,980 kilogram weight. If successful, it will land as a 1,520-kg shell.
The aircraft will reach speeds > 440 km/hr, and will descend by inflating
drag parachutes. Because GlobalFlyer is relatively fragile and was so heavy
at take-off, it is quite susceptible to bad weather. For this reason, the
team has been waiting for several months for a good launch window. Hopes
are high that, weather permitting, GlobalFlyer will succeed at its first
attempt. It won't be Rutan's first entry in the record books, however :
he also designed the rocket SpaceShipOne, which blasted to fame in June
2004 when it became the first privately-funded spacecraft to reach space.
By about 03:30 GMT on 3 March 2005, GlobalFlyer and its pilot Steve Fossett
had reached Hawaii, > 50 hours after taking off from Kansas on 1 March.
The mission control team announced on 2 March that the plane had lost 1,180
kg of fuel during the first few hours of the flight, around 14% of the
8,200 kg that it took off with. The team is not sure how this happened,
although it could be due to a leak or unexpected fuel evaporation. Alternatively,
fuel sensors in the craft's 13 tanks may be giving faulty readings. The
only way that GlobalFlyer can now complete the journey is by gaining speed
from tailwinds, which will need to be at least 58 knots (> 100 km/hr).
Fossett and the team were faced with decisions about whether to continue
the record-breaking adventure before the aircraft headed out across the
Pacific Ocean, and again halfway across, when the plane could have landed
in Hawaii. In order to wing its way around the world without refuelling,
the slender white aircraft was tailor-made to be ultralight and carry 5.5
times its own weight in fuel: just enough for the journey. Fossett touched
down at an airport in Salina, Kansas, at 19:50 GMT on 3 March. He had completed
a non-stop, non-refuelled loop around the globe that took just over 67
hours and was a feat of physical endurance in staying awake. Favourable
tailwinds prevailed, and the aircraft completed the journey in < the
anticipated 80-hour flight time.
invisibility shieldings have
been developed before, but these mostly use the chameleon principle: a
screen is coloured to match its background, so that the screened object
is camouflaged. For example, inventor Ray Alden in North Carolina has proposed
a system of light detectors and emitters that project a replica of the
scene appearing behind an object from its front surface. Researchers at
the University of Tokyo are working on a camouflage fabric that uses a
similar principle, in which the background scene is projected on to light-reflecting
beads in the materialref.
But the invisibility shield proposed by Alù and Engheta is a self-contained
structure that would reduce visibility from all viewing anglesref.
In that sense it would be more like the shielding used by the Romulans
in the Star Trek episode "Balance of Terror" in 1966, which hid their spaceships
at the push of a button. The key to the concept is to reduce light scattering.
We see objects because light bounces off them; if this scattering of light
could be prevented (and if the objects didn't absorb any light) they would
become invisible. Alù and Engheta's plasmonic screen suppresses
scattering by resonating in tune with the illuminating light. Plasmons
are waves of electron density, caused when the electrons on the surface
of a metallic material move in rhythm. A shell of plasmonic material will
scatter light negligibly if the light's frequency is close to the resonant
frequency of the plasmons. The scattering from the shell effectively cancels
out the scattering from the object. For visible-light shielding, nature
has already provided suitable plasmonic materials: silver and gold. To
reduce the scattering of longer-wavelength radiation such as microwaves,
one could make the shield from a 'metamaterial': a large-scale structure
with unusual electromagnetic properties, typically constructed from arrays
of wire loops and coils. Spherical or cylindrical objects coated with such
plasmonic shields do indeed produce very little light scattering. It is
as though, when lit by light of the right wavelength, the objects become
extremely small, so small that they cannot be seen. The concept as it stands
is "no magic cloak", because it would have to be delicately tuned to suit
each different object it hides. Perhaps even more of a drawback is the
fact that a particular shield only works for one specific wavelength of
light. An object might be made invisible in red light, say, but not in
multiwavelength daylight. And crucially, the effect only works when the
wavelength of the light being scattered is roughly the same size as the
object. So shielding from visible light would be possible only for microscopic
objects; larger ones could be hidden only to long-wavelength radiation
such as microwaves. This means that the technology could not be used to
hide people or vehicles from human vision. But that need not undermine
other potential uses. For example, the effect could be useful for making
antiglare materials. Another possible use for plasmonic screening is microscopy.
Light microscopes could surpass their usual resolution limits by using
tiny probes to measure the light field very close to the object being imaged.
Such probes could be made 'invisible' so that they don't disturb the imaging
signal. And of course the shielding would work fine for concealing large
objects such as spaceships from sensors or telescopes that used long-wavelength
radiation instead of visible light.
an analysis of studies in 40 countries around the globe proves a long-standing
assumption: that the more a person knows about science, the more he or
she tends to support scientific endeavours. The issue is a fundamental
one for scientists and science teachers. They often assume that improving
people's scientific literacy will boost support for research, encourage
young people to choose science careers and clear up damaging misconceptions
about miracle cures or pseudoscience. In fact, studies that have tested
the link between a person's level of scientific knowledge and attitudes
towards the field have generated mixed results. The results of nearly 200
surveys carried out between 1998 and 2003 in countries from Australia to
Bulgaria were pulled together : these studies assessed, for example, whether
participants knew certain scientific facts and whether they supported developments
in genetically modified food or nanotechnology. To some extent, the results
confirm the belief widely held by science advocates: the more people
know about science, the more favourably they tend to view it, regardless
of other factors such as age, nationality and formal level of education.
But now this question is cleared up, researchers must begin to tackle more
pressing questions : this finding cannot, for example, show whether better
science education will bump up general support for the field because researchers
have yet to figure out whether people who learn more about science then
tend to like it or, conversely, whether people who already like and support
science are simply inclined to learn further facts. And a person's level
of scientific knowledge actually goes a very tiny way towards explaining
their attitudes towards science. There are probably far more important
factors, such as their moral values, religious beliefs and political leaning.
Many people's stance on embryonic stem-cell research, for example, is thought
to be defined by their moral take on the destruction of human embryos,
not by their precise understanding of the technique involved. And people's
trust in science may be influenced by how tightly regulated they believe
the process to be in their country. This might explain, in part, why those
living in different countries tend to hold different attitudes: Europeans
tend to be more suspicious of genetically modified crops than those in
the USA, for example. Ultimately, science advocates hope to bolster support
for the field, but it looks as if simple science education will not be
enough
Image and Meaning 2, held
from 23 to 25 June 2005 at the Getty art museum in Los Angeles, was the
successor to the first conference of this sort, staged in 2001 at the Massachusetts
Institute of Technology (MIT) in Boston. Scientists, artists, film makers,
designers, writers, editors and art historians were there to explore the
use of images in science, for both understanding data and communicating
it to others. The conference series is the brainchild of Felice Frankel,
a science photographer working at MIT. Frankel helps scientists present
their work using imagery that is both informative and striking. Her photographs
have graced many covers of Nature and Science. Frankel convened the meeting
because we have a serious problem : there is an assumption that in science
our graphics communicate, but they often don't. Many scientists don't see
imagery as an integral part of the scientific process : this is doing the
community a disservice. Many at the conference tackled the notion of how
best to find patterns within their data. Creating graphs or maps becomes
more challenging as the data get more complicated. Some have turned results
into animations to wring meaning from them, whereas others have displayed
their work using virtual reality 'rooms'. There is now a wealth of computer
tools for generating sophisticated imagery. But scientists at the meeting
complained that many of these programs never get beyond the computer-graphics
community that develops them. The audience was impressed when David
Salesin, a computer scientist at the University of Washington, presented
the interactive visual tools that he is developing for Microsoft. Salesin
showed software that can construct realistic-looking aerial photographs
from maps after being trained with a few real photo/map combinations. He
also had programs that could blend different faces, and automatically turn
random objects into 'Escher tiles': these are shapes that can be rotated
to fill a space without leaving any gaps. Salesin's methods got many researchers
thinking about new ways of looking at their findings. But they also raised
a host of questions about proper limits to the manipulation of images.
I had not realised how easy it is to make changes in images seamlessly.
The community should work out rules for what is acceptable in 'improving'
images for publication. On the opposite side of the coin, many argued that
low-tech imagery can have advantages over high-tech in communicating research.
A very polished image can discourage a viewer from engaging with and thinking
about a work. If something is raw, it gives the viewer permission to participate.
Beautiful, computer-generated renderings can also mislead viewers, some
argue, giving a false sense of certainty about the ideas they represent.
Cartoonist and self-described "lapsed mathematician" Larry
Gonick argued that cartoons can be used to great effect in communicating
science without having to turn to expensive or complicated techniques.
Cartooning's graphic style has certain features conducive to explanation.
It invites the eye and draws the reader to the 'main character' of the
illustration. It also comes with a widely understood visual language, he
argues, that can convey motion or narrative. Even the biggest-brained scientists
at this conference have confessed an inability to comprehend some complex
diagrams. Sometimes what one needs to understand a concept is a storyref.
scientists have discovered a way to slow the disintegration of old manuscripts.
The technique involves bathing papers in an organic solution doped with
alkali compounds and antioxidants. These help to tie up atoms of copper
and other metals in the ink that may eat the paper away. It is the
first successful treatment that is not water-based, the researchers announced
at the annual conference of the British Association for the Advancement
of Science in Dublin on 5 September. This means it can be applied to documents
without fear of washing away soluble scribbles, causing books to swell
or ruining leather bindings. The researchers, who have applied for a patent,
say the bath could help to protect kilometres of ancient documents and
manuscripts throughout the world's libraries for many years to come. They
think it should be ready for commercial use in a few years' time. Conservators
have long known that there is something corrosive about inks from the Middle
Ages. Many documents, from sketches by famous artists to political treaties,
have fallen apart over time, with holes appearing where the ink used to
be. To tackle this problem, Jana Kolar, head of the InkCor
project based at the National and University Library of Slovenia in Ljubljana,
and her colleagues sought to uncover the exact constituents of the inks.
Early analyses had indicated that medieval inks are often full of iron.
Free atoms of this metal in the ink react with the air to create oxygen
radicals, reactive atoms that break down cellulose, yellowing paper and
making it brittle. To the horror of scholars, after hundreds of years this
can cause the paper to fall apart. Some ancient recipes specified that
the ink should be a "heavenly blue" rather than coal black. So they suspected
that the main ingredient could be copper, from blue copper sulphate, rather
than iron. They investigated by bombarding old inks with protons, and analysing
the X-rays emitted from the samples. Sure enough, the inks contained copper,
as well as chromium and manganese, which together are more corrosive than
iron alone. They turned their focus to free radical scavengers and antioxidants,
the same compounds that stop cellular damage in humans by tying up particularly
reactive atoms. One such compound had been previously used to stop the
corrosive process of iron in old inks. But this compound, known as phytate,
is metal-specific and so cannot be used with all inks from the old days.
And the phytate process has the disadvantage of being water-based. The
InkCor process combines antioxidants and halides, to stop the degradation,
with alkalies to make the paper less acidic. The whole thing is in an organic
solution of heptane and ethanol, both of which evaporate and so can be
removed from paper easily. The treatment can increase the lifespan of some
ancient papers by > 10 times. The results of the laboratory tests look
promising. The team will next try to apply the method to other materials,
such as leather and silk. These too have highly corrosive colour pigments
that can decompose over time.
the pot of cash for science prizes has just got bigger. In an attempt to
widen the fields covered by the classic Nobel prizes, philanthropist
Fred
Kavli has created 3 million-dollar prizes in nanotechnology, neuroscience
and astrophysics. The Kavli prizes were formally announced by Kristin
Clemet, the Norwegian education minister, on Tuesday 4 May 2005. They will
be awarded every 2 years, starting in 2008. Norwegian-born Kavli, who made
his fortune in California with a company that specialized in making sensors
for aircraft, says he wants to reward scientific breakthroughs. He hopes
his prizes will be more responsive to current research than the Swedish
Nobels. Nobel prizes, awarded in physics, chemistry, medicine, economics,
literature and peace, are often bestowed years or even decades after the
events that merited them. Mathematics is one of the subjects famously omitted
from the Nobels; perhaps, it has been supposed, because Alfred Nobel didn't
see much practical application for the field on its own. But there are
many others that escaped the Nobel remit too. Hefty prizes have been established
over the years in an attempt to make up for this. For scientists aiming
to gain reward and recognition for their efforts, there is now a bewildering
array of such awards to shoot for.
The Royal Swedish Academy of Sciences, which selects the winners of the
physics and chemistry Nobels, hands out smaller prizes for exceptional
research in a somewhat random assortment of fields, including Gregory
Aminoff's prize in crystallography and the Crafoods' prize for polyarthritis
research. A significant enough advance in arthritis can earn a researcher
US$500,000.
Perhaps some of the most prestigious awards in mathematics, although not
necessarily the most lucrative, are Canada's Fields Medal, which
is often equated to a Nobel and comes with a $12,000 cheque, and the Clay
Millennium Problems. The Clay problems comprise 7 of the most taxing
brain-teasers ever committed to paper, and each carries a $1-million bounty.
The judges have not yet been convinced to part with any of the prizes.
The 'genius awards', more properly known as the Macarthur
fellowships, are awarded to a couple of dozen lucky recipients each year.
The fellows are a batch of "exceptionally talented individuals who have
given evidence of originality, dedication to creative pursuits and capacity
for self-direction", and each is given $500,000 in the form of 5 yearly
instalments, to spend on whatever research they wish. There will always
be the awards that gain ample press thanks to their wild or wacky remits,
which capture the imagination.
the $10-million X
Prize for sending humans into space on the back of private funding.
That was snapped up last October by SpaceShipOne, a project funded by Microsoft
co-founder Paul Allen
the Methuselah Mouse Prize, offered
by the Methuselah Foundation,
which offers a portion of its million-dollar-plus pot to those who can
keep a mouse alive past the current record. The benchmark was set by the
oddly-named mouse GHR-KO 11C, which lived almost 5 years (the equivalent
of a 190-year-old human) before dying in early 2003.
Aventis Book Prize
for science books : in 2005 it has been won by Philip
Ball, who bagged the £10,000 (US$19,0000) award for Critical
Mass: How One Thing Leads to Another, which describes how statistics
and physics have been used to explain social phenomena. The book beat stiff
competition from such literary luminaries as Richard Dawkins, Robert Winston
and Richard Fortey. In addition to the prize money, Ball may have won cash
by betting on his own victory. Bookmaker's William Hill said that his book
was the outsider of the competition, quoting 8:1 odds on his winning. "This
is a wide-ranging and dazzlingly informative book about the science of
interactions," says Bill Bryson, chairman of the judging panel and winner
of last year's prize. By explaining the mathematics of human group behaviour,
Critical Mass explores the efforts of physicists and social scientists
to describe the patterns behind economic crashes, stampeding crowds and
the development of traffic jams. Ball received his prize at a ceremony
on 12 May with Robert May, the president of the Royal Society, London,
and Dirk Oldenburg, who is on the board of the pharmaceutical giant Aventis.
Ball worked at Nature as a physical-sciences editor for > 10 years. He
contributes regularly to news@nature.com, and has written about Aventis
winners for this site in the past. He is also science-writer-in-residence
for the chemistry department of University College London. Critical
Mass is his eighth book, with previous publications including The
Ingredients: A Guided Tour of the Elements and H2O: A Biography
of Water. "Throughout his career as an author, Phil has courageously
popularized the science of the commonplace... for materials, colour, water
and now patterns of human behaviour," says Philip Campbell, editor-in-chief
of Nature. "I only hope that this deserved award encourages new readers
to explore his books in all their diversity."
Grand Challenges in Global
Health : imagine being able to do away with vaccines and instead reprogramming
the immune system to attack all kinds of disease. That's the vision of
Caltech's president David Baltimore, who won a Nobel Prize in 1975 for
his work on virology and cancer, and who now has a US$13.9 million grant
to pursue this dream. Baltimore's project is one of 43 that have secured
a portion of $440 million handed out by the Bill
and
Melinda Gates Foundation on 27 June 2005. The cash has been allocated
to daring, innovative projects that aim to beat some of the world's most
problematic diseases. Baltimore's approach is inspired by the continuing
failure to find vaccines that work against the human immunodeficiency virus
(HIV), malaria, cancers and many other diseases. Vaccines work by stimulating
the immune system, but they often use a partial or deactivated form of
the disease agent to provoke this response : sometimes this results in
a very weak immune response that isn't capable of fighting off illness,
either because the wrong type of immune cells are kicked into action, or
because there simply aren't enough of them to do the job, and the immune
response provoked by a jab sometimes wears off with time. One could get
a more complete, stronger response by tapping in directly to where the
body manufactures immune cells such as killer T cells. These protective
agents, which bind onto infected cells and kill them, are produced by stem
cells in the bone marrow. If researchers could genetically modify these
stem cells they could be programmed to create perfectly designed immune
cells, in great quantity and throughout life. Ultimately, a single shot
in infancy could pre-program the immune system with life-long protection
against many diseases. Gene therapy of bone marrow stem cells has been
done in mice, by using a virus to introduce genes into the cells. Baltimore
has begun experiments to see if he can give mice lifelong immunity against
cancers using this method, with promising initial resultsref.
But the technique is in its infancy and has never been used therapeutically
in humans. As an investment, it's very high risk, very visionary. The aim
of the Grand Challenge grants is to attract top basic-research scientists
into work on neglected diseases that mainly affect the poor in developing
countries. The 43 winners were selected from proposals by over 1,500 teams
in 75 countries. Other winners include a project to build a credit card-sized
electronic device which could diagnose a wide range of diseases from a
drop of blood, efforts to boost the nutritional content of staple crops
such as rice and bananas, a project to develop edible vaccines that don't
need to be refrigerated, and an HIV vaccine designed to better protect
women by provoking an immune response directly in the vaginal lining.
MacArthur
fellowships programme at the MacArthur
Foundation, the philanthropic organization based in Chicago, Illinois,
are a set of US$500,000 grants awarded to promising creatives across the
entire sphere of intellectual endeavour. The fellowships, often dubbed
the 'genius awards', are presented each year to a select band of scientists,
artists, writers and thinkers. The money, paid out annually over 5 years,
comes with no strings attached. The 25 fellows on 2005's list come from
a huge range of backgrounds.
Pharmacist Michael Cohen, president of the Institute for Safe Medication
Practices in Huntingdon Valley, Pennsylvania, is committed to stamping
out errors in drug delivery. He claims that these kill thousands of Americans
every year. His institute has championed changes in drug naming to stop
patients being given the wrong prescription accidentally, and advocates
making the pharmaceutical industry more responsible for such errors.
Lobster fisherman and biochemist Ted Ames, based in Stonington, Maine,
aims to combine scientific analysis with his decades of hands-on experience
to develop strategies for managing fisheries on the east coast of the United
States.
And New York native Marin Alsop, now principal conductor of the Bournemouth
Symphony Orchestra, will continue the pioneering work that has seen her
recordings win a string of awards.
The awards are not in recognition of past achievements. We're betting on
the future. In many cases those bets have paid off. The almost 700 previous
recipients include the Internet pioneer Tim Berners-Lee, the elephant conservationist
Cynthia Moss, and the evolutionary biologist Stephen Jay Gould. The fellows
are chosen from a list of nominees provided by a non-permanent panel of
around 100 anonymous, invited nominators. These are whittled down to the
final list by a 12-strong selection committee. The money comes from an
endowment from John MacArthur, who made his millions in insurance sales.
Also featured on 2005's list are Joseph Curtin, a violin-maker seeking
to use 21st-century materials and techniques to create better instruments;
Claire Gmachl, a laser technologist whose work could lead to new techniques
for environmental monitoring and clinical diagnosis; and Jon Kleinberg,
a computer scientist tackling the perennial problem of how to extract the
interesting information embedded in huge data sets such as genome sequences.
They are certainly a talented bunch. But Socolow recoils from the term
'genius awards', thought to have been coined by the New York Times when
the foundation began awarding fellowships in 1981